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Specific Molecular Signatures for Type II Crustins in Penaeid Shrimp Uncovered by the Identification of Crustin-Like Antimicrobial Peptides in Litopenaeus vannamei
Barreto, Caire1; Coelho, Jaqueline da Rosa1; Yuan, Jianbo2; Xiang, Jianhai2; Perazzolo, Luciane Maria1; Rosa, Rafael Diego1
2018
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume16Issue:1Pages:16
Corresponding AuthorRosa, Rafael Diego(rafael.d.rosa@ufsc.br)
AbstractCrustins form a large family of antimicrobial peptides (AMPs) in crustaceans composed of four sub-groups (Types I-IV). Type II crustins (Type IIa or Crustins and Type IIb or Crustin-like) possess a typical hydrophobic N-terminal region and are by far the most representative sub-group found in penaeid shrimp. To gain insight into the molecular diversity of Type II crustins in penaeids, we identified and characterized a Type IIb crustin in Litopenaeus vannamei (Crustin-like Lv) and compared Type II crustins at both molecular and transcriptional levels. Although L. vannamei Type II crustins (Crustin Lv and Crustin-like Lv) are encoded by separate genes, they showed a similar tissue distribution (hemocytes and gills) and transcriptional response to the shrimp pathogens Vibrio harveyi and White spot syndrome virus (WSSV). As Crustin Lv, Crustin-like Lv transcripts were found to be present early in development, suggesting a maternal contribution to shrimp progeny. Altogether, our in silico and transcriptional data allowed to conclude that (1) each sub-type displays a specific amino acid signature at the C-terminal end holding both the cysteine-rich region and the whey acidic protein (WAP) domain, and that (2) shrimp Type II crustins evolved from a common ancestral gene that conserved a similar pattern of transcriptional regulation.
Keywordinvertebrate immunity host defense peptide crustacean WAP domain molecular diversity host-pathogen interaction
DOI10.3390/md16010031
Indexed BySCI
Language英语
Funding ProjectCNPq[MEC/MCTI/CAPES/CNPq/FAPs PVE 401191/2014-1] ; CNPq[MCTI/CNPq Universal 406530/2016-5] ; CAPES[CIMAR 1974/2014] ; National High-Technology Research and Development Program of China (863 program)[2012AA10A404] ; National High-Technology Research and Development Program of China (863 program)[2012AA092205] ; CAPES
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000424125600031
PublisherMDPI AG
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157836
Collection实验海洋生物学重点实验室
Corresponding AuthorRosa, Rafael Diego
Affiliation1.Univ Fed Santa Catarina, Dept Cell Biol Embryol & Genet, Lab Immunol Appl Aquaculture, BR-88040900 Florianopolis, SC, Brazil
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Barreto, Caire,Coelho, Jaqueline da Rosa,Yuan, Jianbo,et al. Specific Molecular Signatures for Type II Crustins in Penaeid Shrimp Uncovered by the Identification of Crustin-Like Antimicrobial Peptides in Litopenaeus vannamei[J]. MARINE DRUGS,2018,16(1):16.
APA Barreto, Caire,Coelho, Jaqueline da Rosa,Yuan, Jianbo,Xiang, Jianhai,Perazzolo, Luciane Maria,&Rosa, Rafael Diego.(2018).Specific Molecular Signatures for Type II Crustins in Penaeid Shrimp Uncovered by the Identification of Crustin-Like Antimicrobial Peptides in Litopenaeus vannamei.MARINE DRUGS,16(1),16.
MLA Barreto, Caire,et al."Specific Molecular Signatures for Type II Crustins in Penaeid Shrimp Uncovered by the Identification of Crustin-Like Antimicrobial Peptides in Litopenaeus vannamei".MARINE DRUGS 16.1(2018):16.
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