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Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1
Zhao, Wei1,2; Wang, Mengqiang1,2; Wang, Lei1,2; Liu, Mei1,2; Jiang, Keyong1,2; Xia, Sudong3; Qi, Cancan1,2; Wang, Baojie1,2
2018-02-02
Source PublicationAQUACULTURE
ISSN0044-8486
Volume485Pages:191-196
Corresponding AuthorWang, Baojie(wangbaojie@qdio.ac.cn)
AbstractAflatoxins are produced in aquaculture feed by the fungi Aspergillus flavus or Aspergillus parasiticus. Aflatoxins can cause severe health problems in shrimp, and thus reduce the yield and profitability of shrimp cultures. We sought to understand the interaction between shrimp metabolism and aflatoxin B1 (AFB1) by analyzing the expression of Litopenaeus vannamei genes related to metabolism, and by analyzing histological alterations of the hepatopancreas, after shrimp were fed with AFB1. After being exposed to 15 ppm AFB1 for 12 d, shrimp exhibited increased mortality and severe histological damage to the hepatopancreas. Metabolism-related genes whose expression is affected by AFB1 are involved in metabolic functions, including the metabolism of pyrimidine, purine, mannose, arginine, proline, glycine, serine, galactose, sphingolipids, valine, leucine and isoleucine, and fatty acids. Our data contribute to our current understanding of how to control AFB1 toxicity through metabolic regulation.
KeywordLitopenaeus vannamei Hepatopancreas Aflatoxin B1 Metabolism Histopathology
DOI10.1016/j.aquaculture.2017.11.044
Indexed BySCI
Language英语
Funding ProjectScience and Technology Major Project of Shandong Province[2015ZDZX05002] ; STS key deployment project of Chinese Academy of Sciences[KFZD-SW-106] ; National Natural Science Foundation of China[41506192]
WOS Research AreaFisheries ; Marine & Freshwater Biology
WOS SubjectFisheries ; Marine & Freshwater Biology
WOS IDWOS:000417627900026
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157757
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Baojie
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Tianjin Fisheries Res Inst, Tianjin 300221, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhao, Wei,Wang, Mengqiang,Wang, Lei,et al. Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1[J]. AQUACULTURE,2018,485:191-196.
APA Zhao, Wei.,Wang, Mengqiang.,Wang, Lei.,Liu, Mei.,Jiang, Keyong.,...&Wang, Baojie.(2018).Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1.AQUACULTURE,485,191-196.
MLA Zhao, Wei,et al."Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1".AQUACULTURE 485(2018):191-196.
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