IOCAS-IR  > 海洋生态与环境科学重点实验室
RNA-seq based transcriptional analysis reveals dynamic genes expression profiles and immune-associated regulation under heat stress in Apostichopus japonicus
Xu, Dongxue; Zhou, Shun; Sun, Lina1
2018-07-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume78Pages:169-176
SubtypeArticle
AbstractIn this study, we explored the gene expression profiles in Apostichopus japonicus under continuous heat stress (6 h, 48 h and 192 h) by applying RNA-seq technique. A total of 676, 1010 and 1083 differentially expressed genes were detected at three heat stress groups respectively, which suggested complex regulation of various biological processes. Then we focused on the changing of immune system under HS in sea cucumbers. Key immune-associated genes were involved in heat stress response, which were classified into six groups: heat shock proteins, transferrin superfamily members, effector genes, proteases, complement system, and pattern recognition receptors and signaling. Moreover, the mRNA expression of the immune-associated genes were validated by the real time PCR. Our results showed that an immunological strategy in this species was developed to confront abrupt elevated temperatures in the environment.
KeywordApostichopus japonicus Heat stress Differentially expressed genes Immune-associated genes
Subject AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
DOI10.1016/j.fsi.2018.04.037
Indexed BySCIE
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000437385000020
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157559
Collection海洋生态与环境科学重点实验室
Affiliation1.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Xu, Dongxue,Zhou, Shun,Sun, Lina. RNA-seq based transcriptional analysis reveals dynamic genes expression profiles and immune-associated regulation under heat stress in Apostichopus japonicus[J]. FISH & SHELLFISH IMMUNOLOGY,2018,78:169-176.
APA Xu, Dongxue,Zhou, Shun,&Sun, Lina.(2018).RNA-seq based transcriptional analysis reveals dynamic genes expression profiles and immune-associated regulation under heat stress in Apostichopus japonicus.FISH & SHELLFISH IMMUNOLOGY,78,169-176.
MLA Xu, Dongxue,et al."RNA-seq based transcriptional analysis reveals dynamic genes expression profiles and immune-associated regulation under heat stress in Apostichopus japonicus".FISH & SHELLFISH IMMUNOLOGY 78(2018):169-176.
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