Institutional Repository of Key Laboratory of Marine Ecology & Environmental Sciences, CAS
| Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers | |
Sun, Lina1; Lin, Chenggang1; Li, Xiaoni1; Xing, Lili1 ; Huo, Da1; Sun, Jingchun1; Zhang, Libin1; Yang, Hongsheng1
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| 2018-07-03 | |
| Source Publication | FRONTIERS IN PHYSIOLOGY
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| ISSN | 1664-042X |
| Volume | 9 |
| Subtype | Article |
| Abstract | Sea cucumbers exposed to stressful circumstances eviscerate most internal organs, and then regenerate them rapidly under favorable environments. Reversible protein phosphorylation and acetylation are major modifications regulating protein function. Herein, for the first time, we perform quantitative phospho- and acetyl proteomics analyses of intestine regeneration in a sea cucumber species Apostichopus japonicus. We identified 1,862 phosphorylation sites in 1,169 proteins, and 712 acetylation sites in 470 proteins. Of the 147 and 251 proteins differentially modified by phosphorylation and acetylation, respectively, most were related to cytoskeleton biogenesis, protein synthesis and modification, signal recognition and transduction, energy production and conversion, or substance transport and metabolism. Phosphorylation appears to play a more important role in signal recognition and transduction than acetylation, while acetylation is of greater importance in posttranslational modification, protein turnover, chaperones; energy production and conversion; amino acid and lipid transport and metabolism. These results expanded our understanding of the regulatory mechanisms of posttranslational modifications in intestine regeneration of sea cucumbers after evisceration. |
| Keyword | sea cucumber intestine regeneration phosphoproteomics acetyl proteomics posttranslational modification |
| Subject Area | Physiology |
| DOI | 10.3389/fphys.2018.00836 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Physiology |
| WOS ID | WOS:000437211600002 |
| Publisher | FRONTIERS MEDIA SA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/157552 |
| Collection | 海洋生态与环境科学重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Sun, Lina,Lin, Chenggang,Li, Xiaoni,et al. Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers[J]. FRONTIERS IN PHYSIOLOGY,2018,9. |
| APA | Sun, Lina.,Lin, Chenggang.,Li, Xiaoni.,Xing, Lili.,Huo, Da.,...&Yang, Hongsheng.(2018).Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers.FRONTIERS IN PHYSIOLOGY,9. |
| MLA | Sun, Lina,et al."Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers".FRONTIERS IN PHYSIOLOGY 9(2018). |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Comparative Phospho-（4566KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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