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Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers
Sun, Lina1; Lin, Chenggang1; Li, Xiaoni1; Xing, Lili1; Huo, Da1; Sun, Jingchun1; Zhang, Libin1; Yang, Hongsheng1
2018-07-03
Source PublicationFRONTIERS IN PHYSIOLOGY
ISSN1664-042X
Volume9
SubtypeArticle
AbstractSea cucumbers exposed to stressful circumstances eviscerate most internal organs, and then regenerate them rapidly under favorable environments. Reversible protein phosphorylation and acetylation are major modifications regulating protein function. Herein, for the first time, we perform quantitative phospho- and acetyl proteomics analyses of intestine regeneration in a sea cucumber species Apostichopus japonicus. We identified 1,862 phosphorylation sites in 1,169 proteins, and 712 acetylation sites in 470 proteins. Of the 147 and 251 proteins differentially modified by phosphorylation and acetylation, respectively, most were related to cytoskeleton biogenesis, protein synthesis and modification, signal recognition and transduction, energy production and conversion, or substance transport and metabolism. Phosphorylation appears to play a more important role in signal recognition and transduction than acetylation, while acetylation is of greater importance in posttranslational modification, protein turnover, chaperones; energy production and conversion; amino acid and lipid transport and metabolism. These results expanded our understanding of the regulatory mechanisms of posttranslational modifications in intestine regeneration of sea cucumbers after evisceration.
Keywordsea cucumber intestine regeneration phosphoproteomics acetyl proteomics posttranslational modification
Subject AreaPhysiology
DOI10.3389/fphys.2018.00836
Indexed BySCIE
Language英语
WOS Research AreaPhysiology
WOS IDWOS:000437211600002
PublisherFRONTIERS MEDIA SA
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157552
Collection海洋生态与环境科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sun, Lina,Lin, Chenggang,Li, Xiaoni,et al. Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers[J]. FRONTIERS IN PHYSIOLOGY,2018,9.
APA Sun, Lina.,Lin, Chenggang.,Li, Xiaoni.,Xing, Lili.,Huo, Da.,...&Yang, Hongsheng.(2018).Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers.FRONTIERS IN PHYSIOLOGY,9.
MLA Sun, Lina,et al."Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers".FRONTIERS IN PHYSIOLOGY 9(2018).
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