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Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers
Sun, Lina1; Lin, Chenggang1; Li, Xiaoni1; Xing, Lili1; Huo, Da1; Sun, Jingchun1; Zhang, Libin1; Yang, Hongsheng1
2018-07-03
发表期刊FRONTIERS IN PHYSIOLOGY
ISSN1664-042X
卷号9
文章类型Article
摘要Sea cucumbers exposed to stressful circumstances eviscerate most internal organs, and then regenerate them rapidly under favorable environments. Reversible protein phosphorylation and acetylation are major modifications regulating protein function. Herein, for the first time, we perform quantitative phospho- and acetyl proteomics analyses of intestine regeneration in a sea cucumber species Apostichopus japonicus. We identified 1,862 phosphorylation sites in 1,169 proteins, and 712 acetylation sites in 470 proteins. Of the 147 and 251 proteins differentially modified by phosphorylation and acetylation, respectively, most were related to cytoskeleton biogenesis, protein synthesis and modification, signal recognition and transduction, energy production and conversion, or substance transport and metabolism. Phosphorylation appears to play a more important role in signal recognition and transduction than acetylation, while acetylation is of greater importance in posttranslational modification, protein turnover, chaperones; energy production and conversion; amino acid and lipid transport and metabolism. These results expanded our understanding of the regulatory mechanisms of posttranslational modifications in intestine regeneration of sea cucumbers after evisceration.
关键词sea cucumber intestine regeneration phosphoproteomics acetyl proteomics posttranslational modification
学科领域Physiology
DOI10.3389/fphys.2018.00836
收录类别SCIE
语种英语
WOS研究方向Physiology
WOS记录号WOS:000437211600002
出版者FRONTIERS MEDIA SA
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/157552
专题海洋生态与环境科学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
第一作者单位中国科学院海洋研究所
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Sun, Lina,Lin, Chenggang,Li, Xiaoni,et al. Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers[J]. FRONTIERS IN PHYSIOLOGY,2018,9.
APA Sun, Lina.,Lin, Chenggang.,Li, Xiaoni.,Xing, Lili.,Huo, Da.,...&Yang, Hongsheng.(2018).Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers.FRONTIERS IN PHYSIOLOGY,9.
MLA Sun, Lina,et al."Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers".FRONTIERS IN PHYSIOLOGY 9(2018).
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