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Genome-wide analysis of gene expression profile in the respiratory tree of sea cucumber (Apostichopus japonicus) in response to hypoxia conditions
Zhang, Libin1; Feng, Qiming1,2; Ding, Kui1,2; Sun, Lina1; Huo, Da1,2; Fang, Yan3; Zhang, Tao1; Yang, Hongsheng1
2018-12-01
Source PublicationJOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM
ISSN0025-3154
Volume98Issue:8Pages:2039-2048
SubtypeArticle; Proceedings Paper
AbstractThe sea cucumber Apostichopus japonicus is a deposit-feeder and vital for marine benthic ecosystems. Hypoxia can influence the behaviour and even lead to massive mortality in A. japonicus in the wild. It is important to understand the molecular responses of A. japonicus when exposed to acute changes in dissolved oxygen (DO) concentration. In this study, RNA-seq provided a general overview of the gene expression profiles of the respiratory tree of A. japonicus exposed to DO of 8 mg l(-1) (DO8), 4 mg l(-1) (DO4) and 2 mg l(-1) (DO2) conditions. Differentially expressed genes (DEGs) screening with the NOISeq method identified 51, 59 and 61 DEGs according to the criteria of fold change >= 2 and divergence probability >= 0.8 in the comparisons of DO2 vs DO4, DO2 vs DO8 and DO4 vs DO8, respectively. Gene ontology analysis showed that 'cellular process' and 'binding' had the most enriched DEGs in the categories of 'biological process' and 'molecular function', respectively (catalytic activity also had the most enriched DEGs in the category of 'molecular function' based on the comparison of DO2 vs DO8), while 'cell' and 'cell part' had the most enriched DEGs in the category of 'cellular component'. The DEGs were mapped to 79, 81 and 104 pathways in the KEGG database, and 8, 29 and 16 pathways were significantly enriched, respectively. The DO-specific DEGs identified in this study of the respiratory tree are important targets for further research into the biochemical mechanisms involved in the response of the sea cucumber to changes in the DO concentration.
KeywordApostichopus japonicus respiratory tree hypoxia stress response metabolic pathway
Subject AreaMarine & Freshwater Biology
DOI10.1017/S002531541700162X
Indexed BySCIE
Language英语
WOS Research AreaMarine & Freshwater Biology
WOS IDWOS:000454077300018
PublisherCAMBRIDGE UNIV PRESS
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157509
Collection海洋生态与环境科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Ludong Univ, Sch Agr, 186 Hongqizhong Rd, Yantai 264025, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
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Zhang, Libin,Feng, Qiming,Ding, Kui,et al. Genome-wide analysis of gene expression profile in the respiratory tree of sea cucumber (Apostichopus japonicus) in response to hypoxia conditions[J]. JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM,2018,98(8):2039-2048.
APA Zhang, Libin.,Feng, Qiming.,Ding, Kui.,Sun, Lina.,Huo, Da.,...&Yang, Hongsheng.(2018).Genome-wide analysis of gene expression profile in the respiratory tree of sea cucumber (Apostichopus japonicus) in response to hypoxia conditions.JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM,98(8),2039-2048.
MLA Zhang, Libin,et al."Genome-wide analysis of gene expression profile in the respiratory tree of sea cucumber (Apostichopus japonicus) in response to hypoxia conditions".JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM 98.8(2018):2039-2048.
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