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Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach
Meng, Ling-Hong; Li, Xiao-Ming; Liu, Yang; Xu, Gang-Ming; Wang, Bin-Gui
2017
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume7Issue:87Pages:55026-55033
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractThe OSMAC (one strain-many compounds) protocol was used in this study to obtain various metabolites from the mangrove-derived endophytic fungus Penicillium brocae MA-231. As a result, four new thiodiketopiperazine alkaloids, penicibrocazines F-I (1-4), together with two new N-containing p-hydroxyphenopyrrozin derivatives brocapyrrozins A and B (7 and 8) as well as six known alkaloids (5, 6, and 9-12), were identified from the extract of the Czapek culture medium of the fungus. Their structures and absolute configurations were determined through interpretation of their spectroscopic data and by X-ray crystallographic analysis. Compounds 7 and 9 exhibited potent activity against human pathogenic bacterium Staphylococcus aureus with MIC values of 0.125 and 0.5 mg mL(-1), respectively.
DOI10.1039/c7ra12081h
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China[81673351] ; Natural Science Foundation of China[31600267] ; Key Laboratory of Marine Bioactive Substance and Modern Analytical Technique, SOA[MBSMAT-2015-05] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016M590667] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017T100521] ; China Postdoctoral Science Foundation[2016M590667] ; China Postdoctoral Science Foundation[2017T100521] ; Taishan Scholar project from Shandong province
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000418378100014
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157392
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
AffiliationChinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Meng, Ling-Hong,Li, Xiao-Ming,Liu, Yang,et al. Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach[J]. RSC ADVANCES,2017,7(87):55026-55033.
APA Meng, Ling-Hong,Li, Xiao-Ming,Liu, Yang,Xu, Gang-Ming,&Wang, Bin-Gui.(2017).Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach.RSC ADVANCES,7(87),55026-55033.
MLA Meng, Ling-Hong,et al."Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach".RSC ADVANCES 7.87(2017):55026-55033.
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