Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi

doi:10.1039/c7ra11122c

IOCAS-IR > 实验海洋生物学重点实验室

	Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi
	Shi, Xiao-Shan1,2,3 ; Wang, Dun-Jia 2; Li, Xiao-Ming 1; Li, Hong-Lei1 ; Meng, Ling-Hong1 ; Li, Xin1 ; Pi, Yan 2; Zhou, Xing-Wang 2; Wang, Bin-Gui1
	2017
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	7 期号:81 页码:51335-51342
通讯作者	Zhou, Xing-Wang(228689100@qq.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要	Artemisia argyi is broadly cultivated as a medicinal plant in Qichun of Hubei province in central China. Five new fungal polyketides (1-5) and two known analogues (6 and 7) were isolated and identified from the culture extract of Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the inner tissue of Artemisia argyi that was collected from Qichun. Their structures were elucidated by detailed interpretation of the spectroscopic data and the structures and absolute configurations of compounds 1-4 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are tricyclic polyketides possessing octahydrochromene framework and having ketal unit in their structures, while compounds 4/7 and 5/6 are related bicyclic and tricyclic analogues, respectively. The antibacterial activities against human pathogen E. coli and seven marine-derived aquatic pathogens as well as against eight agropathogenic fungi for each of the isolated compounds were evaluated. Compounds 1-7 showed activity against human pathogen Escherichia coli (each with MIC 64 mg mL(-1)), while 1 and 7 inhibited most of the tested aquatic bacteria and agro-pathogenic fungi (MICs ranging from 4 to 64 mg mL(-1)), respectively.
DOI	10.1039/c7ra11122c
收录类别	SCI
语种	英语
资助项目	Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000414780700031
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/157273
专题	实验海洋生物学重点实验室
通讯作者	Zhou, Xing-Wang; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Shi, Xiao-Shan,Wang, Dun-Jia,Li, Xiao-Ming,et al. Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi[J]. RSC ADVANCES,2017,7(81):51335-51342.
APA	Shi, Xiao-Shan.,Wang, Dun-Jia.,Li, Xiao-Ming.,Li, Hong-Lei.,Meng, Ling-Hong.,...&Wang, Bin-Gui.(2017).Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi.RSC ADVANCES,7(81),51335-51342.
MLA	Shi, Xiao-Shan,et al."Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi".RSC ADVANCES 7.81(2017):51335-51342.