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Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi
Shi, Xiao-Shan1,2,3; Wang, Dun-Jia2; Li, Xiao-Ming1; Li, Hong-Lei1; Meng, Ling-Hong1; Li, Xin1; Pi, Yan2; Zhou, Xing-Wang2; Wang, Bin-Gui1
2017
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume7Issue:81Pages:51335-51342
Corresponding AuthorZhou, Xing-Wang(228689100@qq.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractArtemisia argyi is broadly cultivated as a medicinal plant in Qichun of Hubei province in central China. Five new fungal polyketides (1-5) and two known analogues (6 and 7) were isolated and identified from the culture extract of Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the inner tissue of Artemisia argyi that was collected from Qichun. Their structures were elucidated by detailed interpretation of the spectroscopic data and the structures and absolute configurations of compounds 1-4 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are tricyclic polyketides possessing octahydrochromene framework and having ketal unit in their structures, while compounds 4/7 and 5/6 are related bicyclic and tricyclic analogues, respectively. The antibacterial activities against human pathogen E. coli and seven marine-derived aquatic pathogens as well as against eight agropathogenic fungi for each of the isolated compounds were evaluated. Compounds 1-7 showed activity against human pathogen Escherichia coli (each with MIC 64 mg mL(-1)), while 1 and 7 inhibited most of the tested aquatic bacteria and agro-pathogenic fungi (MICs ranging from 4 to 64 mg mL(-1)), respectively.
DOI10.1039/c7ra11122c
Indexed BySCI
Language英语
Funding ProjectScientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000414780700031
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157273
Collection实验海洋生物学重点实验室
Corresponding AuthorZhou, Xing-Wang; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Shi, Xiao-Shan,Wang, Dun-Jia,Li, Xiao-Ming,et al. Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi[J]. RSC ADVANCES,2017,7(81):51335-51342.
APA Shi, Xiao-Shan.,Wang, Dun-Jia.,Li, Xiao-Ming.,Li, Hong-Lei.,Meng, Ling-Hong.,...&Wang, Bin-Gui.(2017).Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi.RSC ADVANCES,7(81),51335-51342.
MLA Shi, Xiao-Shan,et al."Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi".RSC ADVANCES 7.81(2017):51335-51342.
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