Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi | |
Shi, Xiao-Shan1,2,3 ; Wang, Dun-Jia2; Li, Xiao-Ming1; Li, Hong-Lei1; Meng, Ling-Hong1; Li, Xin1; Pi, Yan2; Zhou, Xing-Wang2; Wang, Bin-Gui1
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| 2017 | |
| Source Publication | RSC ADVANCES
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| ISSN | 2046-2069 |
| Volume | 7Issue:81Pages:51335-51342 |
| Corresponding Author | Zhou, Xing-Wang(228689100@qq.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | Artemisia argyi is broadly cultivated as a medicinal plant in Qichun of Hubei province in central China. Five new fungal polyketides (1-5) and two known analogues (6 and 7) were isolated and identified from the culture extract of Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the inner tissue of Artemisia argyi that was collected from Qichun. Their structures were elucidated by detailed interpretation of the spectroscopic data and the structures and absolute configurations of compounds 1-4 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are tricyclic polyketides possessing octahydrochromene framework and having ketal unit in their structures, while compounds 4/7 and 5/6 are related bicyclic and tricyclic analogues, respectively. The antibacterial activities against human pathogen E. coli and seven marine-derived aquatic pathogens as well as against eight agropathogenic fungi for each of the isolated compounds were evaluated. Compounds 1-7 showed activity against human pathogen Escherichia coli (each with MIC 64 mg mL(-1)), while 1 and 7 inhibited most of the tested aquatic bacteria and agro-pathogenic fungi (MICs ranging from 4 to 64 mg mL(-1)), respectively. |
| DOI | 10.1039/c7ra11122c |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000414780700031 |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/157273 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Zhou, Xing-Wang; Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Shi, Xiao-Shan,Wang, Dun-Jia,Li, Xiao-Ming,et al. Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi[J]. RSC ADVANCES,2017,7(81):51335-51342. |
| APA | Shi, Xiao-Shan.,Wang, Dun-Jia.,Li, Xiao-Ming.,Li, Hong-Lei.,Meng, Ling-Hong.,...&Wang, Bin-Gui.(2017).Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi.RSC ADVANCES,7(81),51335-51342. |
| MLA | Shi, Xiao-Shan,et al."Antimicrobial polyketides from Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the medicinal plant Artemisia argyi".RSC ADVANCES 7.81(2017):51335-51342. |
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