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Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives
Li, Hong-Lei1,2; Li, Xiao-Ming1; Attila Mandi3; Antus, Sandor3; Li, Xin1; Zhang, Peng1,2; Liu, Yang1,2; Tibor Kurtan3; Wang, Bin-Gui1
2017-10-06
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume82Issue:19Pages:9946-9954
Corresponding AuthorTibor Kurtan(kurtan.tibor@science.unideb.hu) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractFour new cladosporol derivatives, cladosporols F-I (1-4), the known cladosporol C (5), and its new epimer, cladosporol J (6), were isolated and identified from the marine algal-derived endophytic fungus Cladosporium cladosporioides EN-399. Their structures were determined by detailed interpretation of NMR and MS data, and the absolute configurations were established on the basis of TDDFT-ECD and OR calculations. The configurational assignment of cladosporols F (1) and G (2) showed that the previously reported absolute configuration of cladosporol A and all the related cladosporols need to be revised from (4'R) to (4'S). Compounds 1-6 showed antibacterial activity against Escherichia coli, Micrococcus luteus, and Vibrio harveyi with MIC values ranging from 4 to 128 mu g/mL. Compound 3 showed significant cytotoxicity against A549, Huh7, and LM3 cell lines with IC50 values of 5.0, 1.0, and 4.1 mu M, respectively, and compound 5 showed activity against H446 cell line with IC50 value of 4.0 mu M.
DOI10.1021/acs.joc.7b01277
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402] ; National Research, Development and Innovation Office[NKFI K120181] ; National Research, Development and Innovation Office[K112951] ; National Research, Development and Innovation Office[PD121020] ; Taishan Scholar Program from Shandong Province of China
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000412789000003
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157270
Collection实验海洋生物学重点实验室
Corresponding AuthorTibor Kurtan; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Hong-Lei,Li, Xiao-Ming,Attila Mandi,et al. Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(19):9946-9954.
APA Li, Hong-Lei.,Li, Xiao-Ming.,Attila Mandi.,Antus, Sandor.,Li, Xin.,...&Wang, Bin-Gui.(2017).Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives.JOURNAL OF ORGANIC CHEMISTRY,82(19),9946-9954.
MLA Li, Hong-Lei,et al."Characterization of Cladosporols from the Marine Algal-Derived Endophytic Fungus Cladosporium cladosporioides EN-399 and Configurational Revision of the Previously Reported Cladosporol Derivatives".JOURNAL OF ORGANIC CHEMISTRY 82.19(2017):9946-9954.
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