Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501 | |
Li, Hong-Lei1,2 ; Li, Xiao-Ming1; Li, Xin1,2; Wang, Chen-Yin3; Liu, Hui1,2; Kassack, Matthias U.3; Meng, Ling-Hong1; Wang, Bin-Gui1
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| 2017 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| Volume | 80Issue:1Pages:162-168 |
| Corresponding Author | Kassack, Matthias U.(Matthias.Kassack@uni-duesseldorf.de) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | Five new polyhydroxylated hydroanthraquinone derivatives, namely, 8-hydroxyconiothyrinone B (1), 8,11-dihydroxyconiothyrinone B (2), 4R,8-dihydroxyconiothyrinone B (3), 4S,8-dihydroxyconiothyrinone B (4), and 4S,8-dihydroxy-10-O-methyldendryol E (5), were isolated and identified from the culture extract of Talaromyces islandicus EN-501, an endophytic fungus obtained from the inner tissue of the marine red alga Laurencia okamurai. The structures of these compounds were established on the basis of detailed interpretation of their NMR and mass spectroscopic data, and the structures and absolute configurations of compounds 1 and 2 were confirmed by X-ray crystallographic analysis, while the absolute configurations of compounds 3-5 were determined by TDDFT calculations of the ECD spectra. The antimicrobial, antioxidant, and cytotoxic activities of compounds 1-5 were evaluated. |
| DOI | 10.1021/acs.jnatprod.6b00797 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Natural Science Foundation of China[31330009] ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province of China ; Bundesminsterium fur Forschung (BMBF, Germany)[BMBF-16GW0108] |
| WOS Research Area | Plant Sciences ; Pharmacology & Pharmacy |
| WOS Subject | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS ID | WOS:000393089600022 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/157267 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Kassack, Matthias U.; Meng, Ling-Hong; Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qmgdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Heinrich Heine Univ Dusseldorf, Inst Pharmazeut & Med Chem, Univ Str 1, D-40225 Dusseldorf, Germany |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Li, Hong-Lei,Li, Xiao-Ming,Li, Xin,et al. Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(1):162-168. |
| APA | Li, Hong-Lei.,Li, Xiao-Ming.,Li, Xin.,Wang, Chen-Yin.,Liu, Hui.,...&Wang, Bin-Gui.(2017).Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501.JOURNAL OF NATURAL PRODUCTS,80(1),162-168. |
| MLA | Li, Hong-Lei,et al."Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501".JOURNAL OF NATURAL PRODUCTS 80.1(2017):162-168. |
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