Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501

doi:10.1021/acs.jnatprod.6b00797

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	Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501
	Li, Hong-Lei1,2 ; Li, Xiao-Ming 1; Li, Xin1,2 ; Wang, Chen-Yin 3; Liu, Hui1,2 ; Kassack, Matthias U.3; Meng, Ling-Hong1 ; Wang, Bin-Gui1
	2017
Source Publication	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
Volume	80 Issue:1 Pages:162-168
Corresponding Author	Kassack, Matthias U.(Matthias.Kassack@uni-duesseldorf.de) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
Abstract	Five new polyhydroxylated hydroanthraquinone derivatives, namely, 8-hydroxyconiothyrinone B (1), 8,11-dihydroxyconiothyrinone B (2), 4R,8-dihydroxyconiothyrinone B (3), 4S,8-dihydroxyconiothyrinone B (4), and 4S,8-dihydroxy-10-O-methyldendryol E (5), were isolated and identified from the culture extract of Talaromyces islandicus EN-501, an endophytic fungus obtained from the inner tissue of the marine red alga Laurencia okamurai. The structures of these compounds were established on the basis of detailed interpretation of their NMR and mass spectroscopic data, and the structures and absolute configurations of compounds 1 and 2 were confirmed by X-ray crystallographic analysis, while the absolute configurations of compounds 3-5 were determined by TDDFT calculations of the ECD spectra. The antimicrobial, antioxidant, and cytotoxic activities of compounds 1-5 were evaluated.
DOI	10.1021/acs.jnatprod.6b00797
Indexed By	SCI
Language	英语
Funding Project	Natural Science Foundation of China[31330009] ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Taishan Scholar Project from Shandong Province of China ; Bundesminsterium fur Forschung (BMBF, Germany)[BMBF-16GW0108]
WOS Research Area	Plant Sciences ; Pharmacology & Pharmacy
WOS Subject	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS ID	WOS:000393089600022
Publisher	AMER CHEMICAL SOC
Citation statistics	Cited Times:26[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.qdio.ac.cn/handle/337002/157267
Collection	实验海洋生物学重点实验室
Corresponding Author	Kassack, Matthias U.; Meng, Ling-Hong; Wang, Bin-Gui
Affiliation	1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qmgdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Heinrich Heine Univ Dusseldorf, Inst Pharmazeut & Med Chem, Univ Str 1, D-40225 Dusseldorf, Germany
First Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation GB/T 7714	Li, Hong-Lei,Li, Xiao-Ming,Li, Xin,et al. Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(1):162-168.
APA	Li, Hong-Lei.,Li, Xiao-Ming.,Li, Xin.,Wang, Chen-Yin.,Liu, Hui.,...&Wang, Bin-Gui.(2017).Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501.JOURNAL OF NATURAL PRODUCTS,80(1),162-168.
MLA	Li, Hong-Lei,et al."Antioxidant Hydroanthraquinones from the Marine Algal-Derived Endophytic Fungus Talaromyces islandicus EN-501".JOURNAL OF NATURAL PRODUCTS 80.1(2017):162-168.

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