Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480

doi:10.1021/acs.jnatprod.5b00893

IOCAS-IR > 实验海洋生物学重点实验室

	Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480
	Liu, Hui1,2 ; Li, Xiao-Ming 1; Liu, Yang1,2 ; Zhang, Peng1,2 ; Wang, Jia-Ning1,2 ; Wang, Bin-Gui1
	2016-04-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	79 期号:4 页码:806-811
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要	Chermesins A-D (1-4), four new spiromeroterpenoids containing a drimane-type sesquiterpene skeleton, were isolated and identified from the culture extract of Penicillium chermesinum EN-480, an endophytic fungus obtained from the inner tissue of the marine red alga Pterocladiella tenuis. The structures of these new spiromeroterpenoids were elucidated based on detailed spectroscopic analyses, and their absolute configurations were confirmed by single-crystal X-ray diffraction experiments and by ECD data. This is the first report of the crystal structures of spiromeroterpenoids that contain a drimane-type sesquiterpene skeleton with a rare cyclohexa-2,5-dienone unit, which resulted in the unambiguous assignment of their relative and absolute configurations. Compounds 1 and 2 exhibited antibacterial activity against the opportunistic pathogen Micrococcus luteus, with an MIC value of 8 mu g/mL.
DOI	10.1021/acs.jnatprod.5b00893
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402] ; Natural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402]
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000374915800018
出版者	AMER CHEMICAL SOC
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/157249
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Hui,Li, Xiao-Ming,Liu, Yang,et al. Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(4):806-811.
APA	Liu, Hui,Li, Xiao-Ming,Liu, Yang,Zhang, Peng,Wang, Jia-Ning,&Wang, Bin-Gui.(2016).Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480.JOURNAL OF NATURAL PRODUCTS,79(4),806-811.
MLA	Liu, Hui,et al."Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480".JOURNAL OF NATURAL PRODUCTS 79.4(2016):806-811.