Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480 | |
Liu, Hui1,2 ; Li, Xiao-Ming1; Liu, Yang1,2; Zhang, Peng1,2; Wang, Jia-Ning1,2; Wang, Bin-Gui1
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| 2016-04-01 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| Volume | 79Issue:4Pages:806-811 |
| Corresponding Author | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | Chermesins A-D (1-4), four new spiromeroterpenoids containing a drimane-type sesquiterpene skeleton, were isolated and identified from the culture extract of Penicillium chermesinum EN-480, an endophytic fungus obtained from the inner tissue of the marine red alga Pterocladiella tenuis. The structures of these new spiromeroterpenoids were elucidated based on detailed spectroscopic analyses, and their absolute configurations were confirmed by single-crystal X-ray diffraction experiments and by ECD data. This is the first report of the crystal structures of spiromeroterpenoids that contain a drimane-type sesquiterpene skeleton with a rare cyclohexa-2,5-dienone unit, which resulted in the unambiguous assignment of their relative and absolute configurations. Compounds 1 and 2 exhibited antibacterial activity against the opportunistic pathogen Micrococcus luteus, with an MIC value of 8 mu g/mL. |
| DOI | 10.1021/acs.jnatprod.5b00893 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Natural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402] ; Natural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402] |
| WOS Research Area | Plant Sciences ; Pharmacology & Pharmacy |
| WOS Subject | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS ID | WOS:000374915800018 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/157249 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Liu, Hui,Li, Xiao-Ming,Liu, Yang,et al. Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(4):806-811. |
| APA | Liu, Hui,Li, Xiao-Ming,Liu, Yang,Zhang, Peng,Wang, Jia-Ning,&Wang, Bin-Gui.(2016).Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480.JOURNAL OF NATURAL PRODUCTS,79(4),806-811. |
| MLA | Liu, Hui,et al."Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480".JOURNAL OF NATURAL PRODUCTS 79.4(2016):806-811. |
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