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Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480
Liu, Hui1,2; Li, Xiao-Ming1; Liu, Yang1,2; Zhang, Peng1,2; Wang, Jia-Ning1,2; Wang, Bin-Gui1
2016-04-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume79Issue:4Pages:806-811
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractChermesins A-D (1-4), four new spiromeroterpenoids containing a drimane-type sesquiterpene skeleton, were isolated and identified from the culture extract of Penicillium chermesinum EN-480, an endophytic fungus obtained from the inner tissue of the marine red alga Pterocladiella tenuis. The structures of these new spiromeroterpenoids were elucidated based on detailed spectroscopic analyses, and their absolute configurations were confirmed by single-crystal X-ray diffraction experiments and by ECD data. This is the first report of the crystal structures of spiromeroterpenoids that contain a drimane-type sesquiterpene skeleton with a rare cyclohexa-2,5-dienone unit, which resulted in the unambiguous assignment of their relative and absolute configurations. Compounds 1 and 2 exhibited antibacterial activity against the opportunistic pathogen Micrococcus luteus, with an MIC value of 8 mu g/mL.
DOI10.1021/acs.jnatprod.5b00893
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China (NSFC)[31330009] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402]
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000374915800018
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/157249
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
Affiliation1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Hui,Li, Xiao-Ming,Liu, Yang,et al. Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(4):806-811.
APA Liu, Hui,Li, Xiao-Ming,Liu, Yang,Zhang, Peng,Wang, Jia-Ning,&Wang, Bin-Gui.(2016).Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480.JOURNAL OF NATURAL PRODUCTS,79(4),806-811.
MLA Liu, Hui,et al."Chermesins A-D: Meroterpenoids with a Drimane-Type Spirosesquiterpene Skeleton from the Marine Algal-Derived Endophytic Fungus Penicillium chermesinum EN-480".JOURNAL OF NATURAL PRODUCTS 79.4(2016):806-811.
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