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Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1 alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells
Guo, Chuanlong1,2,3,4; Wang, Lijun1,2,3; Jiang, Bo1,2,3; Shi, Dayong1,2,3,4
2018-11-01
Source PublicationANTI-CANCER DRUGS
ISSN0959-4973
Volume29Issue:10Pages:965-974
Corresponding AuthorShi, Dayong(shidayong@qdio.ac.cn)
AbstractThe bromophenol curcumin analog 1,5-bis(3-bromo-4, 5-dimethoxyphenyl) penta-1, 4-dien-3-one (BCA-5) was assayed for antiangiogenic activity. Tandem mass tag labeling and liquid chromatography-tandem mass spectrometry were used to quantify the dynamic changes in the human umbilical vein endothelial cell (HUVEC) proteome. Functional annotation showed that BCA-5 might inhibit compounds related to the extracellular matrix, compounds that possess cytoskeletal protein-binding activity, and compounds that interact with cell motility-related enzymes, indicating antiangiogenic potential. In-vitro experiments have shown that BCA-5 inhibited HUVEC proliferation and induced HUVEC apoptosis. BCA-5 inhibited HUVEC migration, invasion, and tubular formation. BCA-5 decreased the phosphorylation of Akt and endothelial nitric oxide synthase; it also reduced the expression of hypoxia-inducible factor-1 alpha and vascular endothelial cell growth factor in a dose-dependent manner. These results suggest that BCA-5 has antiangiogenic properties and should be considered a potent antiangiogenesis drug for the treatment of cancer. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.
Keywordantiangiogenesis curcumin analogs hypoxia-inducible factor-1 alpha human umbilical vein endothelial cells vascular endothelial growth factor
DOI10.1097/CAD.0000000000000671
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province
WOS Research AreaOncology ; Pharmacology & Pharmacy
WOS SubjectOncology ; Pharmacology & Pharmacy
WOS IDWOS:000448390600005
PublisherLIPPINCOTT WILLIAMS & WILKINS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/156557
Collection实验海洋生物学重点实验室
Corresponding AuthorShi, Dayong
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Guo, Chuanlong,Wang, Lijun,Jiang, Bo,et al. Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1 alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells[J]. ANTI-CANCER DRUGS,2018,29(10):965-974.
APA Guo, Chuanlong,Wang, Lijun,Jiang, Bo,&Shi, Dayong.(2018).Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1 alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells.ANTI-CANCER DRUGS,29(10),965-974.
MLA Guo, Chuanlong,et al."Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1 alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells".ANTI-CANCER DRUGS 29.10(2018):965-974.
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