IOCAS-IR  > 实验海洋生物学重点实验室
Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells
Wang, Xia1,2; Cui, Yan-jun3; Qi, Jia3; Zhu, Min-min3; Zhang, Tian-liang4; Cheng, Min5; Liu, Shun-mei3,4; Wang, Guang-ce6
2018
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6133
Pages11
Corresponding AuthorLiu, Shun-mei(liushm@wfmc.edu.cn) ; Wang, Guang-ce(gcwang@qdio.ac.cn)
AbstractSeveral previous studies have demonstrated the excellent antioxidant activity of fucoxanthin against oxidative stress which is closely related to the pathogenesis of liver diseases. The present work was to investigate whether fucoxanthin could protect human hepatic L02 cells against hydrogen peroxide-(H2O2-) induced oxidative damage. Its effects on H2O2- induced cell viability, lactate dehydrogenase (LDH) leakage, intracellular reduced glutathione, and reactive oxygen species (ROS) contents, along with mRNA and protein relative levels of the cytoprotective genes including Nrf2, HO-1, and NQO1, were investigated. The results showed that fucoxanthin could upregulate the mRNA and protein levels of the cytoprotective genes and promote the nuclear translocation of Nrf2, which could be inhibited by the PI3K inhibitor of LY294002. Pretreatment of fucoxanthin resulted in decreased LDH leakage and intracellular ROS content but enhanced intracellular reduced glutathione. Interestingly, pretreatment using fucoxanthin protected against the oxidative damage in a nonconcentration-dependent manner, with fucoxanthin of 5 mu M demonstrating the optimal effects. The results suggest that fucoxanthin exerts cytoprotective effects against H2O2-induced oxidative damage in L02 cells, which may be through the PI3K-dependent activation of Nrf2 signaling.
DOI10.1155/2018/1085073
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81870237] ; Shandong Provincial Natural Science Foundation, China[ZR2010DM010] ; Shandong Provincial Natural Science Foundation, China[ZR2017LC021] ; Higher Educational Science and Technology Program of Shandong Province[J10LC20]
WOS Research AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS IDWOS:000451147600001
PublisherHINDAWI LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/156169
Collection实验海洋生物学重点实验室
Corresponding AuthorLiu, Shun-mei; Wang, Guang-ce
Affiliation1.Weifang Med Univ, Sch Publ Hlth & Management, Weifang 261053, Peoples R China
2.Weifang Med Univ, Collaborat Innovat Ctr Predict & Governance Major, Weifang 261053, Peoples R China
3.Weifang Med Univ, Sch Biosci & Technol, Weifang 261053, Peoples R China
4.Weifang Med Univ, Expt Ctr Med Res, Weifang 261053, Peoples R China
5.Weifang Med Univ, Sch Clin Med, Weifang 261053, Peoples R China
6.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Xia,Cui, Yan-jun,Qi, Jia,et al. Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells[J]. BIOMED RESEARCH INTERNATIONAL,2018:11.
APA Wang, Xia.,Cui, Yan-jun.,Qi, Jia.,Zhu, Min-min.,Zhang, Tian-liang.,...&Wang, Guang-ce.(2018).Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells.BIOMED RESEARCH INTERNATIONAL,11.
MLA Wang, Xia,et al."Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells".BIOMED RESEARCH INTERNATIONAL (2018):11.
Files in This Item:
File Name/Size DocType Version Access License
Fucoxanthin Exerts C(3124KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Xia]'s Articles
[Cui, Yan-jun]'s Articles
[Qi, Jia]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Xia]'s Articles
[Cui, Yan-jun]'s Articles
[Qi, Jia]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Xia]'s Articles
[Cui, Yan-jun]'s Articles
[Qi, Jia]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.