Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Non-coding RNAs Function as Immune Regulators in Teleost Fish | |
| Wang, Man1; Jiang, Shuai2; Wu, Wei1; Yu, Fei1; Chang, Wenguang1; Li, Peifeng1; Wang, Kun1 | |
| 2018-11-28 | |
| Source Publication | FRONTIERS IN IMMUNOLOGY
 |
| ISSN | 1664-3224 |
| Volume | 9Pages:15 |
| Corresponding Author | Li, Peifeng(peifli@qdu.edu.cn) ; Wang, Kun(wangk696@163.com) |
| Abstract | Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Teleost fish are a highly diverse group among the vertebrate lineage. Fish are also important in terms of aquatic ecosystem, food production and human life, being the source of animal proteins worldwide and models of biomedical research. However, teleost fish always suffer from the invasion of infectious pathogens including viruses and bacteria, which has resulted in a tremendous economic loss to the fishing industry worldwide. Emerging evidence suggests that ncRNAs, especially miRNAs and lncRNAs, may serve as important regulators in cytokine and chemokine signaling, antigen presentation, complement and coagulation cascades, and T cell response in teleost fish. In this review, we summarize current knowledge and understanding of the roles of both miRNAs and lncRNAs in immune regulation in teleost fish. Molecular mechanism insights into the function of ncRNAs in fish immune response may contribute to the development of potential biomarkers and therapeutic targets for the prevention and treatment of fish diseases. |
| Keyword | non-coding RNA fish infectious pathogen immune response immune regulator |
| DOI | 10.3389/fimmu.2018.02801 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch] |
| WOS Research Area | Immunology |
| WOS Subject | Immunology |
| WOS ID | WOS:000451665000002 |
| Publisher | FRONTIERS MEDIA SA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/156139 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Li, Peifeng; Wang, Kun |
| Affiliation | 1.Qingdao Univ, Med Coll, Inst Translat Med, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Man,Jiang, Shuai,Wu, Wei,et al. Non-coding RNAs Function as Immune Regulators in Teleost Fish[J]. FRONTIERS IN IMMUNOLOGY,2018,9:15. |
| APA | Wang, Man.,Jiang, Shuai.,Wu, Wei.,Yu, Fei.,Chang, Wenguang.,...&Wang, Kun.(2018).Non-coding RNAs Function as Immune Regulators in Teleost Fish.FRONTIERS IN IMMUNOLOGY,9,15. |
| MLA | Wang, Man,et al."Non-coding RNAs Function as Immune Regulators in Teleost Fish".FRONTIERS IN IMMUNOLOGY 9(2018):15. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Non-coding RNAs Func（1298KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment