Non-coding RNAs Function as Immune Regulators in Teleost Fish

doi:10.3389/fimmu.2018.02801

IOCAS-IR > 实验海洋生物学重点实验室

	Non-coding RNAs Function as Immune Regulators in Teleost Fish
	Wang, Man 1; Jiang, Shuai 2; Wu, Wei 1; Yu, Fei 1; Chang, Wenguang 1; Li, Peifeng 1; Wang, Kun 1
	2018-11-28
发表期刊	FRONTIERS IN IMMUNOLOGY
ISSN	1664-3224
卷号	9 页码:15
通讯作者	Li, Peifeng(peifli@qdu.edu.cn) ; Wang, Kun(wangk696@163.com)
摘要	Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Teleost fish are a highly diverse group among the vertebrate lineage. Fish are also important in terms of aquatic ecosystem, food production and human life, being the source of animal proteins worldwide and models of biomedical research. However, teleost fish always suffer from the invasion of infectious pathogens including viruses and bacteria, which has resulted in a tremendous economic loss to the fishing industry worldwide. Emerging evidence suggests that ncRNAs, especially miRNAs and lncRNAs, may serve as important regulators in cytokine and chemokine signaling, antigen presentation, complement and coagulation cascades, and T cell response in teleost fish. In this review, we summarize current knowledge and understanding of the roles of both miRNAs and lncRNAs in immune regulation in teleost fish. Molecular mechanism insights into the function of ncRNAs in fish immune response may contribute to the development of potential biomarkers and therapeutic targets for the prevention and treatment of fish diseases.
关键词	non-coding RNA fish infectious pathogen immune response immune regulator
DOI	10.3389/fimmu.2018.02801
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch] ; National Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000451665000002
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/156139
专题	实验海洋生物学重点实验室
通讯作者	Li, Peifeng; Wang, Kun
作者单位	1.Qingdao Univ, Med Coll, Inst Translat Med, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Wang, Man,Jiang, Shuai,Wu, Wei,et al. Non-coding RNAs Function as Immune Regulators in Teleost Fish[J]. FRONTIERS IN IMMUNOLOGY,2018,9:15.
APA	Wang, Man.,Jiang, Shuai.,Wu, Wei.,Yu, Fei.,Chang, Wenguang.,...&Wang, Kun.(2018).Non-coding RNAs Function as Immune Regulators in Teleost Fish.FRONTIERS IN IMMUNOLOGY,9,15.
MLA	Wang, Man,et al."Non-coding RNAs Function as Immune Regulators in Teleost Fish".FRONTIERS IN IMMUNOLOGY 9(2018):15.

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Non-coding RNAs Func（1298KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览