Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| 20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment | |
Li, Xiao-Dong1 ; Li, Xin1,2,3; Li, Xiao-Ming1,2,3; Xu, Gang-Ming1,3; Liu, Yang1; Wang, Bin-Gui1,2,3
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| 2018-11-01 | |
| Source Publication | MARINE DRUGS
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| ISSN | 1660-3397 |
| Volume | 16Issue:11Pages:10 |
| Corresponding Author | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| Abstract | Four new uncommon 20-nor-isopimarane diterpenoid epimers, aspewentins I-L (1-4), together with a new methylated derivative of 3, aspewentin M (5), were isolated from the deep sea sediment-derived fungus Aspergillus wentii SD-310. The very similar structures of these epimers made the separation and purification procedures difficult. The structures of compounds 1-5 were illustrated based on spectroscopic analysis, and the absolute configurations of compounds 1-5 were unambiguously determined by the combination of NOESY, time-dependent density functional (TDDFT)-ECD calculations, and X-ray crystallographic analysis. These metabolites represented the rare examples of 20-nor-isopimarane analogues possessing a cyclohexa-2,5-dien-1-one moiety. These compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria, as well as plant-pathogenic fungi. While compounds 1 and 2 exhibited inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio harveyi, and V. parahaemolyticus, compound 5 showed potent activity against the plant pathogen Fusarium graminearum. |
| Keyword | sediment-derived fungus Aspergillus wentii 20-nor-isopimarane epimers antimicrobial activity |
| DOI | 10.3390/md16110440 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key R&D Program of China[2018YFC0310800] ; National Natural Science Foundation of China[31700043] ; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2016ASKJ14] |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:000451159500043 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/156103 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Wang, Bin-Gui |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Li, Xiao-Dong,Li, Xin,Li, Xiao-Ming,et al. 20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment[J]. MARINE DRUGS,2018,16(11):10. |
| APA | Li, Xiao-Dong,Li, Xin,Li, Xiao-Ming,Xu, Gang-Ming,Liu, Yang,&Wang, Bin-Gui.(2018).20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment.MARINE DRUGS,16(11),10. |
| MLA | Li, Xiao-Dong,et al."20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment".MARINE DRUGS 16.11(2018):10. |
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