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Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)
Zhang, Peng1; Li, Xin2; Yuan, Xiao-Long1; Du, Yong-Mei1; Wang, Bin-Gui2; Zhang, Zhong-Feng1
2018-12-01
发表期刊MOLECULES
ISSN1420-3049
卷号23期号:12页码:7
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Zhang, Zhong-Feng(zhangzhongfeng@caas.cn)
摘要An endophytic fungus Arthrinium arundinis TE-3 was isolated and purified from the fresh leaves of cultivated tobacco (Nicotiana tabacum L.). Chemical investigation on this fungal strain afforded three new prenylated diphenyl ethers (1-3) as well as three known analogues (4-6). Structure elucidation of the isolated compounds was carried out by analysis of 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectra, as well as by comparison of those data with literature data. The absolute configuration of the stereogenic center at C-8 in 1 was assigned by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 showed selective antifungal activity against Mucor hiemalis with minimum inhibitory concentration (MIC) values of 8 and 4 g/mL, respectively. Compounds 5 and 6 exhibited inhibitory activity against Alteraria alternata with an MIC value of 8 g/mL. In the cytotoxic assay, 2, 5, and 6 displayed moderate in vitro cytotoxicity against the human monocytic cell line (THP-1 cell line), with IC50 values of 40.2, 28.3, and 25.9 M, respectively. This study indicated that endophytic fungi possess great potential for exploring new bioactive secondary metabolites.
关键词tobacco-derived endophytic fungus Arthrinium arundinis Nicotiana tabacum L prenylated diphenyl ethers antifungal activity cytotoxicity
DOI10.3390/molecules23123179
收录类别SCI
语种英语
资助项目Natural Science Foundation of China[31700295] ; Natural Science Foundation of China[31700295]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000454523000129
出版者MDPI
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/155962
专题实验海洋生物学重点实验室
通讯作者Wang, Bin-Gui; Zhang, Zhong-Feng
作者单位1.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China
2.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol, Inst Oceanol,Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
通讯作者单位中国科学院海洋研究所
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GB/T 7714
Zhang, Peng,Li, Xin,Yuan, Xiao-Long,et al. Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)[J]. MOLECULES,2018,23(12):7.
APA Zhang, Peng,Li, Xin,Yuan, Xiao-Long,Du, Yong-Mei,Wang, Bin-Gui,&Zhang, Zhong-Feng.(2018).Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.).MOLECULES,23(12),7.
MLA Zhang, Peng,et al."Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)".MOLECULES 23.12(2018):7.
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