Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)

doi:10.3390/molecules23123179

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	Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)
	Zhang, Peng1 ; Li, Xin2 ; Yuan, Xiao-Long 1; Du, Yong-Mei 1; Wang, Bin-Gui2 ; Zhang, Zhong-Feng 1
	2018-12-01
Source Publication	MOLECULES
ISSN	1420-3049
Volume	23 Issue:12 Pages:7
Corresponding Author	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Zhang, Zhong-Feng(zhangzhongfeng@caas.cn)
Abstract	An endophytic fungus Arthrinium arundinis TE-3 was isolated and purified from the fresh leaves of cultivated tobacco (Nicotiana tabacum L.). Chemical investigation on this fungal strain afforded three new prenylated diphenyl ethers (1-3) as well as three known analogues (4-6). Structure elucidation of the isolated compounds was carried out by analysis of 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectra, as well as by comparison of those data with literature data. The absolute configuration of the stereogenic center at C-8 in 1 was assigned by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 showed selective antifungal activity against Mucor hiemalis with minimum inhibitory concentration (MIC) values of 8 and 4 g/mL, respectively. Compounds 5 and 6 exhibited inhibitory activity against Alteraria alternata with an MIC value of 8 g/mL. In the cytotoxic assay, 2, 5, and 6 displayed moderate in vitro cytotoxicity against the human monocytic cell line (THP-1 cell line), with IC50 values of 40.2, 28.3, and 25.9 M, respectively. This study indicated that endophytic fungi possess great potential for exploring new bioactive secondary metabolites.
Keyword	tobacco-derived endophytic fungus Arthrinium arundinis Nicotiana tabacum L prenylated diphenyl ethers antifungal activity cytotoxicity
DOI	10.3390/molecules23123179
Indexed By	SCI
Language	英语
Funding Project	Natural Science Foundation of China[31700295]
WOS Research Area	Biochemistry & Molecular Biology ; Chemistry
WOS Subject	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS ID	WOS:000454523000129
Publisher	MDPI
Citation statistics
Document Type	期刊论文
Identifier	http://ir.qdio.ac.cn/handle/337002/155962
Collection	实验海洋生物学重点实验室
Corresponding Author	Wang, Bin-Gui; Zhang, Zhong-Feng
Affiliation	1.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol, Inst Oceanol,Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
Corresponding Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation GB/T 7714	Zhang, Peng,Li, Xin,Yuan, Xiao-Long,et al. Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)[J]. MOLECULES,2018,23(12):7.
APA	Zhang, Peng,Li, Xin,Yuan, Xiao-Long,Du, Yong-Mei,Wang, Bin-Gui,&Zhang, Zhong-Feng.(2018).Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.).MOLECULES,23(12),7.
MLA	Zhang, Peng,et al."Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)".MOLECULES 23.12(2018):7.

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