Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.) | |
Zhang, Peng1![]() ![]() ![]() | |
2018-12-01 | |
Source Publication | MOLECULES
![]() |
ISSN | 1420-3049 |
Volume | 23Issue:12Pages:7 |
Corresponding Author | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Zhang, Zhong-Feng(zhangzhongfeng@caas.cn) |
Abstract | An endophytic fungus Arthrinium arundinis TE-3 was isolated and purified from the fresh leaves of cultivated tobacco (Nicotiana tabacum L.). Chemical investigation on this fungal strain afforded three new prenylated diphenyl ethers (1-3) as well as three known analogues (4-6). Structure elucidation of the isolated compounds was carried out by analysis of 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectra, as well as by comparison of those data with literature data. The absolute configuration of the stereogenic center at C-8 in 1 was assigned by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 showed selective antifungal activity against Mucor hiemalis with minimum inhibitory concentration (MIC) values of 8 and 4 g/mL, respectively. Compounds 5 and 6 exhibited inhibitory activity against Alteraria alternata with an MIC value of 8 g/mL. In the cytotoxic assay, 2, 5, and 6 displayed moderate in vitro cytotoxicity against the human monocytic cell line (THP-1 cell line), with IC50 values of 40.2, 28.3, and 25.9 M, respectively. This study indicated that endophytic fungi possess great potential for exploring new bioactive secondary metabolites. |
Keyword | tobacco-derived endophytic fungus Arthrinium arundinis Nicotiana tabacum L prenylated diphenyl ethers antifungal activity cytotoxicity |
DOI | 10.3390/molecules23123179 |
Indexed By | SCI |
Language | 英语 |
Funding Project | Natural Science Foundation of China[31700295] |
WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
WOS ID | WOS:000454523000129 |
Publisher | MDPI |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.qdio.ac.cn/handle/337002/155962 |
Collection | 实验海洋生物学重点实验室 |
Corresponding Author | Wang, Bin-Gui; Zhang, Zhong-Feng |
Affiliation | 1.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol, Inst Oceanol,Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China |
Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Zhang, Peng,Li, Xin,Yuan, Xiao-Long,et al. Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)[J]. MOLECULES,2018,23(12):7. |
APA | Zhang, Peng,Li, Xin,Yuan, Xiao-Long,Du, Yong-Mei,Wang, Bin-Gui,&Zhang, Zhong-Feng.(2018).Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.).MOLECULES,23(12),7. |
MLA | Zhang, Peng,et al."Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)".MOLECULES 23.12(2018):7. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
Antifungal Prenylate(820KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment