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Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)
Zhang, Peng1; Li, Xin2; Yuan, Xiao-Long1; Du, Yong-Mei1; Wang, Bin-Gui2; Zhang, Zhong-Feng1
2018-12-01
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:12Pages:7
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Zhang, Zhong-Feng(zhangzhongfeng@caas.cn)
AbstractAn endophytic fungus Arthrinium arundinis TE-3 was isolated and purified from the fresh leaves of cultivated tobacco (Nicotiana tabacum L.). Chemical investigation on this fungal strain afforded three new prenylated diphenyl ethers (1-3) as well as three known analogues (4-6). Structure elucidation of the isolated compounds was carried out by analysis of 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectra, as well as by comparison of those data with literature data. The absolute configuration of the stereogenic center at C-8 in 1 was assigned by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 showed selective antifungal activity against Mucor hiemalis with minimum inhibitory concentration (MIC) values of 8 and 4 g/mL, respectively. Compounds 5 and 6 exhibited inhibitory activity against Alteraria alternata with an MIC value of 8 g/mL. In the cytotoxic assay, 2, 5, and 6 displayed moderate in vitro cytotoxicity against the human monocytic cell line (THP-1 cell line), with IC50 values of 40.2, 28.3, and 25.9 M, respectively. This study indicated that endophytic fungi possess great potential for exploring new bioactive secondary metabolites.
Keywordtobacco-derived endophytic fungus Arthrinium arundinis Nicotiana tabacum L prenylated diphenyl ethers antifungal activity cytotoxicity
DOI10.3390/molecules23123179
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China[31700295]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000454523000129
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/155962
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui; Zhang, Zhong-Feng
Affiliation1.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China
2.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol, Inst Oceanol,Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Peng,Li, Xin,Yuan, Xiao-Long,et al. Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)[J]. MOLECULES,2018,23(12):7.
APA Zhang, Peng,Li, Xin,Yuan, Xiao-Long,Du, Yong-Mei,Wang, Bin-Gui,&Zhang, Zhong-Feng.(2018).Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.).MOLECULES,23(12),7.
MLA Zhang, Peng,et al."Antifungal Prenylated Diphenyl Ethers from Arthrinium arundinis, an Endophytic Fungus Isolated from the Leaves of Tobacco (Nicotiana tabacum L.)".MOLECULES 23.12(2018):7.
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