Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae)

doi:10.1016/j.bse.2018.08.002

IOCAS-IR > 实验海洋生物学重点实验室

	Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae)
	Xu, Kuo 1,2; Guo, Shuju 1,2; Jia, Xiaoling 1,2; Li, Xiang 4; Shi, Dayong 1,2,3
	2018-12-01
发表期刊	BIOCHEMICAL SYSTEMATICS AND ECOLOGY
ISSN	0305-1978
卷号	81 页码:42-44
通讯作者	Shi, Dayong(shidayong@qdio.ac.cn)
摘要	A phytochemical study on whole Leathesia nana plants led to isolation of 22 compounds, including 12 bromophenols (1-12), 1 megastigmane sesquiterpene (13), 4 monoindole alkaloids (14-17), and 5 other small mond lecules (18-22). Their structures were elucidated by H-1 and C-13 NMR spectroscopy, HRESIMS data, and by comparison with closely related compounds published previously. Compounds 8-11, 13, 14, and 17-22 were first reported from Leathesia nana, while 1-7, 12, 15, and 16 had been previously isolated, which could be considered chemotaxonomic markers. In addition, the biological activities of all of the compounds were evaluated with protein tyrosine phosphatase 1b (PTP1B). Compounds 1-3 and 5-7 exhibited potent inhibitory effects on PTP1B with IC50 values of 9.40, 4.30, 7.94, 14.64, 16.40, and 10.95 mu M, respectively, while the other compounds showed no obvious activities (IC50 values > 20 mu M.
关键词	Leathesia nana Chordariaceae Bromophenol Chemotaxonomy PTP1B
DOI	10.1016/j.bse.2018.08.002
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81803375] ; National Postdoctoral Program for Innovative Talents[BX201700247] ; China Postdoctoral Science Foundation[2018M630804] ; Natural Science Foundation of Shandong Province[ZR2016DQ07] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Natural Science Foundation of China[81803375] ; National Postdoctoral Program for Innovative Talents[BX201700247] ; China Postdoctoral Science Foundation[2018M630804] ; Natural Science Foundation of Shandong Province[ZR2016DQ07] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
WOS研究方向	Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
WOS类目	Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology
WOS记录号	WOS:000452565100009
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/155805
专题	实验海洋生物学重点实验室
通讯作者	Shi, Dayong
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Ocean Univ China, Coll Marine Life Sci, Qingdao 266100, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Kuo,Guo, Shuju,Jia, Xiaoling,et al. Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae)[J]. BIOCHEMICAL SYSTEMATICS AND ECOLOGY,2018,81:42-44.
APA	Xu, Kuo,Guo, Shuju,Jia, Xiaoling,Li, Xiang,&Shi, Dayong.(2018).Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae).BIOCHEMICAL SYSTEMATICS AND ECOLOGY,81,42-44.
MLA	Xu, Kuo,et al."Phytochemical and chemotaxonomic study on Leathesia nana (Chordariaceae)".BIOCHEMICAL SYSTEMATICS AND ECOLOGY 81(2018):42-44.

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