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Comparative study of beta-thymosin in two scallop species Argopecten irradians and Chlamys farreri
Wang, Mengqiang1,3; Wang, Baojie1; Liu, Mei1; Jiang, Keyong1; Wang, Lei1,2,4
2019-03-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
卷号86页码:516-524
通讯作者Wang, Lei(wanglei@qdio.ac.cn)
摘要The beta-thymosin (T beta) proteins participate in numerous biological processes, such as cell proliferation and differentiation, anti-inflammatory and antimicrobial mechanism. To date, T beta proteins have been well studied in vertebrates, especially mammals. While limited T beta or T beta-like proteins have been reported in invertebrates. Moreover, rare information of T beta or T beta-like proteins is available in scallop species yet. In the present study, two T beta homologues, AiT beta and CfT beta, were identified and characterized from two scallop species bay scallop Argopecten irradians and Zhikong scallop Chlamys farreri. They were both 41 amino acid peptide and contained one THY domain, a highly conserved actin-binding motif and two conserved helix forming regions. Tissue distribution and expression profiles of their mRNA transcripts were roughly similar yet different in detail, while their recombinant proteins exhibited different immunomodulation activity on the downstream immune parameters. These results collectively indicated that the function of T beta family in scallop were functionally differentiated.
关键词beta-thymosin Innate immunity Immunomodulation
DOI10.1016/j.fsi.2018.11.050
收录类别SCI
语种英语
资助项目STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; Aoshan Innovation Project in Science and Technology from National Laboratory for Marine Science and Technology[2016ASKJ07] ; National Natural Science Foundation of China[U1706209] ; National Natural Science Foundation of China[U1706209] ; Aoshan Innovation Project in Science and Technology from National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号WOS:000459528400060
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/155418
专题实验海洋生物学重点实验室
通讯作者Wang, Lei
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Natl Lab Marine Sci & Technol, Res Platform Marine Mol Biotechnol, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, CAS Ctr Ocean Mega Sci, Qingdao 266400, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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Wang, Mengqiang,Wang, Baojie,Liu, Mei,et al. Comparative study of beta-thymosin in two scallop species Argopecten irradians and Chlamys farreri[J]. FISH & SHELLFISH IMMUNOLOGY,2019,86:516-524.
APA Wang, Mengqiang,Wang, Baojie,Liu, Mei,Jiang, Keyong,&Wang, Lei.(2019).Comparative study of beta-thymosin in two scallop species Argopecten irradians and Chlamys farreri.FISH & SHELLFISH IMMUNOLOGY,86,516-524.
MLA Wang, Mengqiang,et al."Comparative study of beta-thymosin in two scallop species Argopecten irradians and Chlamys farreri".FISH & SHELLFISH IMMUNOLOGY 86(2019):516-524.
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