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Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy
Zhang, Enhui1,2,3; Xing, Ronge1,2,3; Liu, Song1,2,3; Li, Kecheng1,2,3; Qin, Yukun1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
2019-04-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume126Pages:662-672
Corresponding AuthorXing, Ronge(xingronge@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
AbstractA gastric cancer angiogenesis marker peptide, GX1, is promising to be a desirable ligand for anti-angiogenesis targeted drug of gastric cancer treatment. In this study, GX1 was utilized to fabricate a multifunctional vascular targeting docetaxel (DCT)-loaded nanoparticle with N-deoxycholic acid glycol chitosan (DGC) as the carrier and GX1-PEG-deoxycholic acid (GPD) conjugate as the targeting ligand. The mean size of obtained GX1-DGC-DCT was 150.9 nm with a narrow size distribution and their shape was spherical with smooth surface texture. The in vitro drug release test revealed a sustained release manner and an acid pH could accelerate the release compared with the neutral pH. Furthermore, GX1-DGC-DCT showed stronger cytotoxicity against co-cultured gastric cancer cells and human umbilical vein endothelial cells (co-HUVEC) than DCT within 100 mu M. In addition, GX1 efficiently enhanced the cellular uptake of nanoparticles in co-HUVEC cells as confirmed by confocal fluorescence scanning microscopy. Moreover, in vivo delivery of GX1-DGC-DCT was demonstrated to inhibit tumor growth in SGC791 tumor-bearing mice with tumor inhibition rate (TIR) of 67.05% and no weight loss of mice was observed. The anti-tumor effects were further confirmed by H&E and TUNEL analysis. Therefore, this new drug delivery system represents a potential strategy for gastric cancer therapy. (C) 2019 Elsevier B.V. All rights reserved.
KeywordTargeted drug delivery Chitosan Docetaxel
DOI10.1016/j.ijbiomac.2018.12.262
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFC0311305] ; Special projects of Foshan science and technology innovation team[2017IT100054]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000460710000076
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/155298
Collection实验海洋生物学重点实验室
Corresponding AuthorXing, Ronge; Li, Pengcheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Enhui,Xing, Ronge,Liu, Song,et al. Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,126:662-672.
APA Zhang, Enhui.,Xing, Ronge.,Liu, Song.,Li, Kecheng.,Qin, Yukun.,...&Li, Pengcheng.(2019).Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,126,662-672.
MLA Zhang, Enhui,et al."Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 126(2019):662-672.
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