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The Effect of Melatonin on Locomotor Behavior and Muscle Physiology in the Sea Cucumber Apostichopus japonicus
Ding, Kui1,2,3,4; Zhang, Libin1,2,3,4; Zhang, Tao1,2,3,4; Yang, Hongsheng1,2,3,4; Brinkman, Richard5
2019-03-19
Source PublicationFRONTIERS IN PHYSIOLOGY
ISSN1664-042X
Volume10Pages:13
Corresponding AuthorZhang, Libin(zhanglibin@qdio.ac.cn)
AbstractMelatonin is a highly conserved hormone in evolutionary history. It occurs in numerous organisms and plays a role in the endocrine and immune systems. Locomotor behavior is a basic behavior in animals and is an important indicator of circadian rhythms, which are coordinated by the nervous and endocrine systems. To date, the effect of melatonin on locomotor behavior has been studied in vertebrates, including syrian hamsters, sparrows, rats, zebrafish, goldfish, and flatworms. However, there have been few studies of the effects of melatonin on locomotor behavior in marine invertebrates. The goals of present study were to show the existence of melatonin in the sea cucumber Apostichopus japonicus and to evaluate its effect on locomotor activity. In addition, muscle tissues from control and melatonin-treated sea cucumbers were tested using ultra performance liquid chromatography and quadrupole time-offlight mass spectrometry (UPLC-Q-TOF-MS) to determine the changes of metabolic activity in muscle. Melatonin was present in the coelomic fluid of A. japonicus at a concentration of similar to 135.0 ng/L. The total distance traveled and number steps taken over 9 h after melatonin administration decreased with increasing concentration of the melatonin dose. Mean and maximum velocity of movement and stride length and stride frequency also decreased, but their differences were not statistically significant. Overall, these results suggest that melatonin administration had a sedative effect on A. japonicus. The levels of 22 different metabolites were altered in the muscle tissues of melatonin-treated sea cucumbers. Serotonin, 9-cis retinoic acid, all-trans retinoic acid, flavin mononucleotide in muscles were downregulated after melatonin administration. Moreover, a high free fatty acid (FFA) concentration and a decrease in the adenosine 5'-triphosphate (ATP) concentration in the muscle tissues of the melatonin-treated group were detected as well. These results suggest that the sedative effect of melatonin involves some other metabolic pathways, and the reduced locomotor modulator- serotonin, inhibited fatty acid oxidation and disturbed oxidative phosphorylation are potential physiological mechanisms that result in the inhibitory effect of melatonin on locomotion in sea cucumbers.
Keywordmelatonin sea cucumber locomotor behavior physiological mechanism fatty acid oxidation oxidative phosphorylation
DOI10.3389/fphys.2019.00221
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Plan[2016YFE0101500] ; National Natural Science Foundation of China[41676136] ; Funding of Youth Innovation Promotion Association, CAS[2015163] ; Creative Team Project of the Laboratory for Marine Ecology and Environmental Science ; Qingdao National Laboratory for Marine Science and Technology[LMEES-CTSP-2018-1] ; Taishan Scholars Program
WOS Research AreaPhysiology
WOS SubjectPhysiology
WOS IDWOS:000461732100001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/155287
Collection海洋生态与环境科学重点实验室
Corresponding AuthorZhang, Libin
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
5.Australian Inst Marine Sci, Townsville, Qld, Australia
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Ding, Kui,Zhang, Libin,Zhang, Tao,et al. The Effect of Melatonin on Locomotor Behavior and Muscle Physiology in the Sea Cucumber Apostichopus japonicus[J]. FRONTIERS IN PHYSIOLOGY,2019,10:13.
APA Ding, Kui,Zhang, Libin,Zhang, Tao,Yang, Hongsheng,&Brinkman, Richard.(2019).The Effect of Melatonin on Locomotor Behavior and Muscle Physiology in the Sea Cucumber Apostichopus japonicus.FRONTIERS IN PHYSIOLOGY,10,13.
MLA Ding, Kui,et al."The Effect of Melatonin on Locomotor Behavior and Muscle Physiology in the Sea Cucumber Apostichopus japonicus".FRONTIERS IN PHYSIOLOGY 10(2019):13.
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