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Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp
Zhu, Guanghui1,2; Li, Shihao3,4,5; Wu, Jun2; Li, Fuhua3,4,5; Zhao, Xing-Ming1
2019-03-11
Source PublicationFRONTIERS IN PHYSIOLOGY
ISSN1664-042X
Volume10Pages:9
Corresponding AuthorLi, Fuhua(fhli@qdio.ac.cn) ; Zhao, Xing-Ming(xmzhao@fudan.edu.cn)
AbstractWhite spot syndrome virus (WSSV) is one of the major threats to shrimp aquaculture. It has been found that the signal transducer and activator of transcription (STAT) protein plays an important role in the antiviral immunity of shrimp with a WSSV infection. However, the mechanism that underlies the STAT-mediated antiviral responses in shrimp, against WSSV infection, remains unclear. In this work, based on the gene expression profiles of shrimp with an injection of WSSV and STAT double strand RNA (dsRNA), we constructed a gene co-expression network for shrimp and identified the gene modules that are possibly responsible for STAT-mediated antiviral responses. These gene modules are found enriched in the regulation of the viral process, JAK-STAT cascade and the regulation of immune effector process pathways. The gene modules identified here provide insights into the molecular mechanism that underlies the STAT-mediated antiviral response of shrimp, against WSSV.
Keywordantivirus response co-expression network gene module STAT dsRNA white spot syndrome virus shrimp
DOI10.3389/fphys.2019.00212
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[61772368] ; National Natural Science Foundation of China[61572363] ; National Natural Science Foundation of China[91530321] ; Natural Science Foundation of Shanghai[17ZR1445600] ; Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China[OF2015NO13]
WOS Research AreaPhysiology
WOS SubjectPhysiology
WOS IDWOS:000460860100001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/155263
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Fuhua; Zhao, Xing-Ming
Affiliation1.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China
2.Tongji Univ, Dept Comp Sci & Technol, Shanghai, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhu, Guanghui,Li, Shihao,Wu, Jun,et al. Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp[J]. FRONTIERS IN PHYSIOLOGY,2019,10:9.
APA Zhu, Guanghui,Li, Shihao,Wu, Jun,Li, Fuhua,&Zhao, Xing-Ming.(2019).Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp.FRONTIERS IN PHYSIOLOGY,10,9.
MLA Zhu, Guanghui,et al."Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp".FRONTIERS IN PHYSIOLOGY 10(2019):9.
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