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Insights into individual variations in nematocyst venoms from the giant jellyfish Nemopilema nomurai in the Yellow Sea
Yue, Yang1,3; Yu, Huahua1,2,3; Li, Rongfeng1,2,3; Liu, Song1,2,3; Xing, Ronge1,2,3; Li, Pengcheng1,2,3
2019-03-04
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号9页码:13
通讯作者Yu, Huahua(yuhuahua@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
摘要The giant jellyfish, Nemopilema nomurai, is widely distributed from the Eastern China Sea to the northern part of the Yellow Sea and has resulted in numerous hospitalizations in coastal areas of China, especially in Northern China. Our previous studies have revealed sting-related proteins in the venom of the jellyfish N. nomurai by using experimental and omics-based approaches; however, the variable symptoms of patients who have been stung by N. nomurai are not fully understood. This limited knowledge led to an examination of whether intraspecific variations occur in the venom of different N. nomurai. In the present study, 13 specimens of N. nomurai were collected from the Yellow Sea, and their venom was characterized by profiling differences in biochemical properties and biological activities. SDS-PAGE analysis presented recognizable differences in the number, intensity and presence of some protein bands. Moreover, enzymatic assays revealed considerable quantitative variations in metalloproteinase activity and PLA2-like activity. In particular, zymography assays of proteases demonstrated the general presence of abundant metalloproteinases in jellyfish nematocyst venom; however, the catalytic activities varied greatly among some specific metalloproteinases in the 28-46 kDa or 57-83 kDa range. Hemolytic assays using sheep erythrocytes suggested a predominant variance in the toxicities of different individual jellyfish venoms, with the difference between the most hemolytic and the least hemolytic venom as large as 77-fold. The current data suggested remarkable variations in the nematocyst venoms of individual N. nomurai jellyfish. These observations will provide a new understanding of the clinical manifestations induced by N. nomurai jellyfish stings and will therefore have important implications for preventing and treating jellyfish envenomations.
DOI10.1038/s41598-019-40109-4
收录类别SCI
语种英语
资助项目Qingdao Science and Technology Project[17-3-3-21-nsh] ; Key Research and Development Plan of Shandong Province[2017GHY215003] ; National Key RD Plan[2017YFE0111100-04] ; National Natural Science Foundation of China[41406152] ; National Natural Science Foundation of China[41376004] ; National Natural Science Foundation of China[41876164] ; National Natural Science Foundation of China[41776163] ; National Natural Science Foundation of China[41776163] ; National Natural Science Foundation of China[41876164] ; National Natural Science Foundation of China[41376004] ; National Natural Science Foundation of China[41406152] ; National Key RD Plan[2017YFE0111100-04] ; Key Research and Development Plan of Shandong Province[2017GHY215003] ; Qingdao Science and Technology Project[17-3-3-21-nsh]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000460123600033
出版者NATURE PUBLISHING GROUP
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/155229
专题实验海洋生物学重点实验室
通讯作者Yu, Huahua; Li, Pengcheng
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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Yue, Yang,Yu, Huahua,Li, Rongfeng,et al. Insights into individual variations in nematocyst venoms from the giant jellyfish Nemopilema nomurai in the Yellow Sea[J]. SCIENTIFIC REPORTS,2019,9:13.
APA Yue, Yang,Yu, Huahua,Li, Rongfeng,Liu, Song,Xing, Ronge,&Li, Pengcheng.(2019).Insights into individual variations in nematocyst venoms from the giant jellyfish Nemopilema nomurai in the Yellow Sea.SCIENTIFIC REPORTS,9,13.
MLA Yue, Yang,et al."Insights into individual variations in nematocyst venoms from the giant jellyfish Nemopilema nomurai in the Yellow Sea".SCIENTIFIC REPORTS 9(2019):13.
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