Knowledge Management System Of The Institute of Oceanology, CAS
|Place of Conferral||中国科学院海洋研究所|
|Keyword||生物有机金属复合物 壳聚糖席夫碱 抗真菌|
Plant diseases cause considerable losses to crop yields every year. Plant pathogenic fungi are one of the main causes of plant diseases. Chemical pesticides have been used to control plant diseases for a long time. Among them, metal pesticides are widely used because of their advantages such as low cost, broad antimicrobial spectrum and strong sterilization effect. However, the use of metal fungicides will also cause problems such as phytotoxicity and heavy metal contamination. Therefore, the design and synthesis of natural organic metal pesticides based on traditional chemical metal pesticides is the main direction of research and development of metal pesticides. Chitosan is a natural macromolecule compound. It is innoxious and harmless and is rich in resources. Chitosan has antifungal effects, but its application is limited because of its poor effect and poor water solubility. Hence, we expect that grafting Schiff base and metal ions onto chitosan may result in the development of a new metal complex with a novel character and enhanced antifungal activity, so as to solve the problems of traditional metal fungicides.
In this paper, the chitosan obtained from marine organisms was chemically modified by Schiff base and metal complexation respectively. Fourteen kinds of chitosan Schiff bases and twenty-four kinds of chitosan Schiff base complexes were synthesized. The physical and chemical properties of the derivatives were comprehensively analyzed by infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), elemental analysis, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). At the same time, the new density functional theory (DFT) was used, and the molecular conformations of chitosan derivatives were calculated with the combination of computational chemistry. The bactericidal spectrum of chitosan derivatives was investigated through the antifungal activity experiments in vitro. Four kinds of derivatives were screened out for pot experiments, 18 derivatives were tested for phytotoxicity and cytotoxicity. The main results were as the followings:
In this paper, six kinds of chitosan derivatives with novel structure and good antifungal activity were prepared and screened, and their phytotoxicity and other characteristics were studied. The derivatives basically retain the advantages of chitosan, such as low toxicity and good biocompatibility. Moreover, the antifungal activity of the derivatives is better than that of thiediazole copper and oligosaccharides. The experimental results may provide a novel direction for the development of metal fungicides, and the characterization of new derivatives provides a novel research idea in structural analysis.
|MOST Discipline Catalogue||理学::海洋科学|
|Table of Contents|
|刘卫翔. 壳聚糖基有机金属配合物的设计、合成及其抗菌活性研究[D]. 中国科学院海洋研究所. 中国科学院大学,2018.|
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