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Progestin is important for testicular development of male turbot (Scophthalmus maximus) during the annual reproductive cycle through functionally distinct progestin receptors
Feng, Chengcheng1,2,3; Xu, Shihong1,3; Liu, Yifan1,3; Wang, Yanfeng1,3; Wang, Wenqi4; Yang, Jingkun4; Zhao, Chunyan1,2,3; Liu, Qinghua1,3; Li, Jun1,3
2018-02-01
Source PublicationFISH PHYSIOLOGY AND BIOCHEMISTRY
Volume44Issue:1Pages:35-48
SubtypeArticle
AbstractIn teleost, sex steroid hormones are critical for reproduction. Progestin is known to promote spermiation. To further understand the functions of progestin via its receptors during the annual reproductive cycle in male turbot (Scophthalmus maximus), we observed testicular development, quantified several sex steroid hormones, detected the expression of progestin receptors, and measured various sperm parameters. Results showed that the turbot testicular structure was of the lobular type. During breeding season, a number of spermatocytes (stage III) developed into spermatids (stage IV), then differentiated into sperm during spermiogenesis (stage V), and finally regressed to spermatocytes (stage VI). Concomitant with testicular development, serum progesterone (P4) and 17 alpha,20 beta-dihydroxy-4-pregnen-3-one (DHP) exhibited higher levels from stage IV to V than other stages. Furthermore, males with higher motility sperm showed higher levels of P4 and DHP compared with fish with lower motility sperm. These results indicated that P4 and DHP might induce spermatogenesis due to seasonal changes. Concurrently, in testes, the nuclear progesterone receptor (pgr) was expressed throughout the reproductive cycle and its level peaked during spermiogenesis while expression of membrane progestin receptor alpha (mPR alpha) did not change significantly. However, in sperm, mPR alpha expression was higher than in testes and had a significant positive correlation with curvilinear velocities (VCL), sperm motility, and motility duration. In conclusion, progestin appears to exert a direct pgr-mediated effect on spermiogenesis and improve sperm motility characteristics depending on the abundance of mPR alpha protein in sperm during spermiation.
KeywordSex Steroid Hormones Progestin Receptors Testicular Development Sperm Motility Scophthalmus Maximus
DOI10.1007/s10695-017-0411-y
Indexed BySCI
Language英语
WOS IDWOS:000423826500004
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/154338
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266061, Peoples R China
4.Qingdao Agr Univ, Marine Sci & Engn Coll, Qingdao 266109, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Feng, Chengcheng,Xu, Shihong,Liu, Yifan,et al. Progestin is important for testicular development of male turbot (Scophthalmus maximus) during the annual reproductive cycle through functionally distinct progestin receptors[J]. FISH PHYSIOLOGY AND BIOCHEMISTRY,2018,44(1):35-48.
APA Feng, Chengcheng.,Xu, Shihong.,Liu, Yifan.,Wang, Yanfeng.,Wang, Wenqi.,...&Li, Jun.(2018).Progestin is important for testicular development of male turbot (Scophthalmus maximus) during the annual reproductive cycle through functionally distinct progestin receptors.FISH PHYSIOLOGY AND BIOCHEMISTRY,44(1),35-48.
MLA Feng, Chengcheng,et al."Progestin is important for testicular development of male turbot (Scophthalmus maximus) during the annual reproductive cycle through functionally distinct progestin receptors".FISH PHYSIOLOGY AND BIOCHEMISTRY 44.1(2018):35-48.
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