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Integrating the Vibrio-resistance phenotype and gene expression data for discovery of markers used for resistance evaluation in the clam Meretrix petechialis
Jiang, Fengjuan1,2; Wang, Hongxia1; Yue, Xin1; Zhang, Shujing1,2; Liu, Baozhong1,3
2018
发表期刊AQUACULTURE
卷号482页码:130-136
文章类型Article
摘要In this study, gene expression data were used to select resistance-associated markers that indicate resistance phenotypes in the clam Meretrix petechialis. A total of 1772 clams from 23 full-sibling families were subjected to a Vibrio challenge test, and the results showed significant variation in resistance to vibriosis among different families. Three of the most resistant families and three of the most susceptible families were selected for screening of resistance-associated markers. Then, among 22 genes, 12 demonstrated a significant change in expression, and their expression levels were further analysed by t-test and linear regression analyses, respectively, between resistant and susceptible families. Overall, the results showed that the basal expression levels of Big-Def, BIRC7, NFIL3, CTL9 and Bax were associated with Vibrio-resistant phenotypes and could be considered candidate resistance-associated markers. Further, two M. petechialis strains that differed in Vibrio resistance were used to examine the effectiveness of these five resistance-associated genes. The results further confirmed that the expression of BIRC7 and NFIL3 were associated with Vibrio-resistant phenotypes. This study integrated the Vibrio-resistance phenotype and gene expression data for resistance evaluation and provided potential markers for the genetic breeding of high Vibrio-resistance strains in the clam M. petechialis.
关键词Meretrix Petechialis Vibrio Parahaemolyticus Resistance Gene Expression Level Molecular Markers
DOI10.1016/j.aquaculture.2017.09.033
收录类别SCI
语种英语
WOS记录号WOS:000413434400020
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143229
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266000, Peoples R China
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Jiang, Fengjuan,Wang, Hongxia,Yue, Xin,et al. Integrating the Vibrio-resistance phenotype and gene expression data for discovery of markers used for resistance evaluation in the clam Meretrix petechialis[J]. AQUACULTURE,2018,482:130-136.
APA Jiang, Fengjuan,Wang, Hongxia,Yue, Xin,Zhang, Shujing,&Liu, Baozhong.(2018).Integrating the Vibrio-resistance phenotype and gene expression data for discovery of markers used for resistance evaluation in the clam Meretrix petechialis.AQUACULTURE,482,130-136.
MLA Jiang, Fengjuan,et al."Integrating the Vibrio-resistance phenotype and gene expression data for discovery of markers used for resistance evaluation in the clam Meretrix petechialis".AQUACULTURE 482(2018):130-136.
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