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Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis
Jiang, Shuai1,2; Sun, Li1,2
2017-09-01
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号18期号:9
文章类型Article
摘要CD209 is an immune receptor that plays an important role in the initiation of innate immunity and activation of adaptive immunity in mammals. However, much less is known about the immunological function of CD209 in lower vertebrates. In the present study, we examined the immune effect of a CD209 homologue (CsCD209) from the teleost fish tongue sole Cynoglossus semilaevis. CsCD209 possesses a lectin domain that shares high levels of similarity with the lectin domains of human and mouse CD209. CsCD209 expression was most abundant in kidney and blood and was significantly upregulated during bacterial infection. CsCD209 exhibited a subcellular localization mainly on the cell surface of myelomonocytes. Recombinant CsCD209 displayed apparent binding capacities to a broad range of bacteria and fungi, and significantly promoted the phagocytosis of the bound bacteria by C. semilaevis leukocytes. Collectively, the results indicate that teleost CD209 serves as a pattern recognition receptor that exerts an influence on the phagocytosis process during pathogen infections.
关键词Cd209 Lectin Cynoglossus Semilaevis Microbial Recognition Phagocytosis
DOI10.3390/ijms18091848
收录类别SCI
语种英语
WOS记录号WOS:000411963800027
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文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143226
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
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Jiang, Shuai,Sun, Li. Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(9).
APA Jiang, Shuai,&Sun, Li.(2017).Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(9).
MLA Jiang, Shuai,et al."Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.9(2017).
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