IOCAS-IR  > 实验海洋生物学重点实验室
Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis
Jiang, Shuai1,2; Sun, Li1,2
2017-09-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume18Issue:9
SubtypeArticle
AbstractCD209 is an immune receptor that plays an important role in the initiation of innate immunity and activation of adaptive immunity in mammals. However, much less is known about the immunological function of CD209 in lower vertebrates. In the present study, we examined the immune effect of a CD209 homologue (CsCD209) from the teleost fish tongue sole Cynoglossus semilaevis. CsCD209 possesses a lectin domain that shares high levels of similarity with the lectin domains of human and mouse CD209. CsCD209 expression was most abundant in kidney and blood and was significantly upregulated during bacterial infection. CsCD209 exhibited a subcellular localization mainly on the cell surface of myelomonocytes. Recombinant CsCD209 displayed apparent binding capacities to a broad range of bacteria and fungi, and significantly promoted the phagocytosis of the bound bacteria by C. semilaevis leukocytes. Collectively, the results indicate that teleost CD209 serves as a pattern recognition receptor that exerts an influence on the phagocytosis process during pathogen infections.
KeywordCd209 Lectin Cynoglossus Semilaevis Microbial Recognition Phagocytosis
DOI10.3390/ijms18091848
Indexed BySCI
Language英语
WOS IDWOS:000411963800027
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143226
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jiang, Shuai,Sun, Li. Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(9).
APA Jiang, Shuai,&Sun, Li.(2017).Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(9).
MLA Jiang, Shuai,et al."Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.9(2017).
Files in This Item:
File Name/Size DocType Version Access License
Tongue Sole CD209_ A(8563KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jiang, Shuai]'s Articles
[Sun, Li]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jiang, Shuai]'s Articles
[Sun, Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jiang, Shuai]'s Articles
[Sun, Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Tongue Sole CD209_ A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.