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Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii
Wang, Jun-Feng1,2; Liang, Rui3; Liao, Sheng-Rong1; Yang, Bin1; Tu, Zheng-Chao3; Lin, Xiu-Ping1; Wang, Bin-Gui2; Liu, Yonghong1,4,5
2017-07-01
Source PublicationFITOTERAPIA
Volume120Pages:164-170
SubtypeArticle
AbstractTen new salicyloid derivatives, namely vaccinols J-S (1-10), along with five known compounds (11-15) were isolated from Pestalotiopsis vaccinii (cgmcc3.9199) endogenous with the mangrove plant Kandelia candel (L.) Druce (Rhizophoraceae). Their structures including absolute configurations were established on the basis of spectroscopic analysis, optical rotation, CD spectra, quantum ECD calculations. To the best of our knowledge, vaccinol J (1) is the first example of salicyloid derivatives containing 2-methylfuran moiety. All of the new compounds were tested for their anti-enterovirus 71 (EV71) and cytotoxic activities. Among them, vaccinol J (1) exhibited in vitro anti-EV71 with IC50 value of 30.7 mu M (IC50 177.0 mu M for the positive control ribavirin).
KeywordEndophytic Fungus Pestalotiopsis Vaccinii Salicyloid Anti-enterovirus 71 Activity
DOI10.1016/j.fitote.2017.06.013
Indexed BySCI
Language英语
WOS IDWOS:000407404000024
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143098
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.South China Sea Bioresource Exploitat & Utilizat, Guangzhou, Guangdong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Jun-Feng,Liang, Rui,Liao, Sheng-Rong,et al. Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii[J]. FITOTERAPIA,2017,120:164-170.
APA Wang, Jun-Feng.,Liang, Rui.,Liao, Sheng-Rong.,Yang, Bin.,Tu, Zheng-Chao.,...&Liu, Yonghong.(2017).Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii.FITOTERAPIA,120,164-170.
MLA Wang, Jun-Feng,et al."Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii".FITOTERAPIA 120(2017):164-170.
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