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Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii
Wang, Jun-Feng1,2; Liang, Rui3; Liao, Sheng-Rong1; Yang, Bin1; Tu, Zheng-Chao3; Lin, Xiu-Ping1; Wang, Bin-Gui2; Liu, Yonghong1,4,5
2017-07-01
发表期刊FITOTERAPIA
卷号120页码:164-170
文章类型Article
摘要Ten new salicyloid derivatives, namely vaccinols J-S (1-10), along with five known compounds (11-15) were isolated from Pestalotiopsis vaccinii (cgmcc3.9199) endogenous with the mangrove plant Kandelia candel (L.) Druce (Rhizophoraceae). Their structures including absolute configurations were established on the basis of spectroscopic analysis, optical rotation, CD spectra, quantum ECD calculations. To the best of our knowledge, vaccinol J (1) is the first example of salicyloid derivatives containing 2-methylfuran moiety. All of the new compounds were tested for their anti-enterovirus 71 (EV71) and cytotoxic activities. Among them, vaccinol J (1) exhibited in vitro anti-EV71 with IC50 value of 30.7 mu M (IC50 177.0 mu M for the positive control ribavirin).
关键词Endophytic Fungus Pestalotiopsis Vaccinii Salicyloid Anti-enterovirus 71 Activity
DOI10.1016/j.fitote.2017.06.013
收录类别SCI
语种英语
WOS记录号WOS:000407404000024
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143098
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.South China Sea Bioresource Exploitat & Utilizat, Guangzhou, Guangdong, Peoples R China
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Wang, Jun-Feng,Liang, Rui,Liao, Sheng-Rong,et al. Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii[J]. FITOTERAPIA,2017,120:164-170.
APA Wang, Jun-Feng.,Liang, Rui.,Liao, Sheng-Rong.,Yang, Bin.,Tu, Zheng-Chao.,...&Liu, Yonghong.(2017).Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii.FITOTERAPIA,120,164-170.
MLA Wang, Jun-Feng,et al."Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii".FITOTERAPIA 120(2017):164-170.
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