DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis

doi:10.1387/ijdb.160175sj

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	DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis
	Sun, Wei 1,2; Jiao, Shuang 1,2; Tan, Xungang1,2 ; Zhang, Peijun 1,2; You, Feng 1,2
	2017
发表期刊	INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷号	61 期号:6-7 页码:459-463
文章类型	Article
摘要	Dual specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) is a serine/threonine kinase. In zebrafish, DYRK2 is expressed in the lateral somites and adaxial cells at the early stage of embryo development. However, its role in early myogenesis had not been elucidated yet. Here, we report that DYRK2 mRNA and MyoD mRNA were colocalized in the muscle progenitor cells in somites, including both the posterior compartment of the lateral somites and adaxial cells. Knockdown of DYRK2 reduced the levels of MyoD transcripts in the muscle progenitor cells in somites. In contrast, overexpression of DYRK2 increased the levels of MyoD transcripts in the muscle progenitor cells in somites. The effects of knockdown and overexpression of DYRK2 on the expression of MyoD in the posterior compartment of the lateral somites were much greater than in the adaxial cells. Further studies indicated that forced expression of DYRK2 increased the levels of fast-twitch skeletal myosin RNA. Moreover, knockdown or forced expression of DYRK2 affected the levels of fast-twitch skeletal myosin protein. Together, these data indicate that DYRK2 is expressed in the developing muscle progenitor cells in somites and that it positively regulates fast-twitch muscle differentiation, at least at the early stages.
关键词	Zebrafish Dyrk2 In Situ Hybridization Muscle Development
DOI	10.1387/ijdb.160175sj
收录类别	SCI
语种	英语
WOS记录号	WOS:000406369000013
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/143095
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Sun, Wei,Jiao, Shuang,Tan, Xungang,et al. DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY,2017,61(6-7):459-463.
APA	Sun, Wei,Jiao, Shuang,Tan, Xungang,Zhang, Peijun,&You, Feng.(2017).DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis.INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY,61(6-7),459-463.
MLA	Sun, Wei,et al."DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis".INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 61.6-7(2017):459-463.

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