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Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas
Li, Yingxiang1,2,3; Zhang, Linlin1,2,3; Qu, Tao1,2,3; Tang, Xueying1,2,3,4; Li, Li1,2,3; Zhang, Guofan1,2,3
2017-07-01
Source PublicationCELL DEATH & DISEASE
Volume8
SubtypeArticle
AbstractApoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite controversial. In this study, we investigated the molecular mechanism of mitochondrial apoptosis in the Pacific oyster Crassostrea gigas. Notably, we show that most key elements involved in the vertebrate mitochondrial apoptosis pathway - including mitochondrial outer membrane permeabilization, cytochrome c release, and caspase activation - are also present in C. gigas. In contrast, the lack of Bcl-2 homology 3-only subfamily members and apoptotic protease activating factor-1 (APAF-1) protein revealed evolutionary diversity from other phyla. Our results support that mitochondrial apoptosis in animals predates the emergence of vertebrates, but suggest that an unexpectedly diverse mitochondrial apoptosis pathway may exist in invertebrates. In addition, our work provided new clues for an improved understanding of how bivalve acclimate themselves to an inconstant environment.
DOI10.1038/cddis.2017.307
Indexed BySCI
Language英语
WOS IDWOS:000406870400004
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143094
Collection海洋生物技术研发中心
实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Yingxiang,Zhang, Linlin,Qu, Tao,et al. Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas[J]. CELL DEATH & DISEASE,2017,8.
APA Li, Yingxiang,Zhang, Linlin,Qu, Tao,Tang, Xueying,Li, Li,&Zhang, Guofan.(2017).Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas.CELL DEATH & DISEASE,8.
MLA Li, Yingxiang,et al."Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas".CELL DEATH & DISEASE 8(2017).
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