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Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas
Li, Yingxiang1,2,3; Zhang, Linlin1,2,3; Qu, Tao1,2,3; Tang, Xueying1,2,3,4; Li, Li1,2,3; Zhang, Guofan1,2,3
2017-07-01
发表期刊CELL DEATH & DISEASE
卷号8
文章类型Article
摘要Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite controversial. In this study, we investigated the molecular mechanism of mitochondrial apoptosis in the Pacific oyster Crassostrea gigas. Notably, we show that most key elements involved in the vertebrate mitochondrial apoptosis pathway - including mitochondrial outer membrane permeabilization, cytochrome c release, and caspase activation - are also present in C. gigas. In contrast, the lack of Bcl-2 homology 3-only subfamily members and apoptotic protease activating factor-1 (APAF-1) protein revealed evolutionary diversity from other phyla. Our results support that mitochondrial apoptosis in animals predates the emergence of vertebrates, but suggest that an unexpectedly diverse mitochondrial apoptosis pathway may exist in invertebrates. In addition, our work provided new clues for an improved understanding of how bivalve acclimate themselves to an inconstant environment.
DOI10.1038/cddis.2017.307
收录类别SCI
语种英语
WOS记录号WOS:000406870400004
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文献类型期刊论文
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条目标识符http://ir.qdio.ac.cn/handle/337002/143094
专题海洋生物技术研发中心
实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
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GB/T 7714
Li, Yingxiang,Zhang, Linlin,Qu, Tao,et al. Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas[J]. CELL DEATH & DISEASE,2017,8.
APA Li, Yingxiang,Zhang, Linlin,Qu, Tao,Tang, Xueying,Li, Li,&Zhang, Guofan.(2017).Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas.CELL DEATH & DISEASE,8.
MLA Li, Yingxiang,et al."Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas".CELL DEATH & DISEASE 8(2017).
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