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Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates
Bao, Yongbo1,2; Xu, Fei3,4,5; Shimeld, Sebastian M.1
2017-04-01
Source PublicationGENOME BIOLOGY AND EVOLUTION
Volume9Issue:4Pages:869-886
SubtypeArticle
AbstractThe gain and loss of genes encoding transcription factors is of importance to understanding the evolution of gene regulatory complexity. The basic helix-loop-helix (bHLH) genes encode a large superfamily of transcription factors. We systematically classify the bHLH genes from five mollusc, two annelid and one brachiopod genomes, tracing the pattern of bHLH gene evolution across these poorly studied Phyla. In total, 56-88 bHLH genes were identified in each genome, with most identifiable as members of previously described bilaterian families, or of new families we define. Of such families only one, Mesp, appears lost by all these species. Additional duplications have also played a role in the evolution of the bHLH gene repertoire, with many new lophotrochozoan-, mollusc-, bivalve-, or gastropod-specific genes defined. Using a combination of transcriptome mining, RT-PCR, and in situ hybridization we compared the expression of several of these novel genes in tissues and embryos of the molluscs Crassostrea gigas and Patella vulgata, finding both conserved expression and evidence for neofunctionalization. We also map the positions of the genes across these genomes, identifying numerous gene linkages. Some reflect recent paralog divergence by tandem duplication, others are remnants of ancient tandem duplications dating to the lophotrochozoan or bilaterian common ancestors. These data are built into a model of the evolution of bHLH genes in molluscs, showing formidable evolutionary stasis at the family level but considerable within-family diversification by tandem gene duplication.
KeywordBhlh Gene Mollusc Annelid Transcription Factor Gene Duplication
DOI10.1093/gbe/evx047
Indexed BySCI
Language英语
WOS IDWOS:000406755800005
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143092
Collection实验海洋生物学重点实验室
Affiliation1.Univ Oxford, Dept Zool, Oxford, England
2.Zhejiang Wanli Univ, Coll Biol & Environm Sci, Zhejiang Key Lab Aquat Germplasm Resources, Ningbo, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Bao, Yongbo,Xu, Fei,Shimeld, Sebastian M.. Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates[J]. GENOME BIOLOGY AND EVOLUTION,2017,9(4):869-886.
APA Bao, Yongbo,Xu, Fei,&Shimeld, Sebastian M..(2017).Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates.GENOME BIOLOGY AND EVOLUTION,9(4),869-886.
MLA Bao, Yongbo,et al."Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates".GENOME BIOLOGY AND EVOLUTION 9.4(2017):869-886.
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