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Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates
Bao, Yongbo1,2; Xu, Fei3,4,5; Shimeld, Sebastian M.1
2017-04-01
发表期刊GENOME BIOLOGY AND EVOLUTION
卷号9期号:4页码:869-886
文章类型Article
摘要The gain and loss of genes encoding transcription factors is of importance to understanding the evolution of gene regulatory complexity. The basic helix-loop-helix (bHLH) genes encode a large superfamily of transcription factors. We systematically classify the bHLH genes from five mollusc, two annelid and one brachiopod genomes, tracing the pattern of bHLH gene evolution across these poorly studied Phyla. In total, 56-88 bHLH genes were identified in each genome, with most identifiable as members of previously described bilaterian families, or of new families we define. Of such families only one, Mesp, appears lost by all these species. Additional duplications have also played a role in the evolution of the bHLH gene repertoire, with many new lophotrochozoan-, mollusc-, bivalve-, or gastropod-specific genes defined. Using a combination of transcriptome mining, RT-PCR, and in situ hybridization we compared the expression of several of these novel genes in tissues and embryos of the molluscs Crassostrea gigas and Patella vulgata, finding both conserved expression and evidence for neofunctionalization. We also map the positions of the genes across these genomes, identifying numerous gene linkages. Some reflect recent paralog divergence by tandem duplication, others are remnants of ancient tandem duplications dating to the lophotrochozoan or bilaterian common ancestors. These data are built into a model of the evolution of bHLH genes in molluscs, showing formidable evolutionary stasis at the family level but considerable within-family diversification by tandem gene duplication.
关键词Bhlh Gene Mollusc Annelid Transcription Factor Gene Duplication
DOI10.1093/gbe/evx047
收录类别SCI
语种英语
WOS记录号WOS:000406755800005
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143092
专题实验海洋生物学重点实验室
作者单位1.Univ Oxford, Dept Zool, Oxford, England
2.Zhejiang Wanli Univ, Coll Biol & Environm Sci, Zhejiang Key Lab Aquat Germplasm Resources, Ningbo, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
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Bao, Yongbo,Xu, Fei,Shimeld, Sebastian M.. Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates[J]. GENOME BIOLOGY AND EVOLUTION,2017,9(4):869-886.
APA Bao, Yongbo,Xu, Fei,&Shimeld, Sebastian M..(2017).Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates.GENOME BIOLOGY AND EVOLUTION,9(4),869-886.
MLA Bao, Yongbo,et al."Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates".GENOME BIOLOGY AND EVOLUTION 9.4(2017):869-886.
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