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Crystal structures of the isochorismatase domains from Vibrio anguillarum
Du, Jiansen1,2; Deng, Tian1,2; Ma, Qingjun1,2
2017-08-26
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume490Issue:3Pages:827-833
SubtypeArticle
AbstractAntibiotic resistance is becoming a global threat and overuse of antibiotics in aquaculture disease control worsens the situation. To reduce the risk of drug resistance developed in aquaculture, safer biocontrol programs are needed. Antivirulence therapy, with less chance for developing drug resistance, is a promising approach. To facilitate antivirulence inhibitor design against Vibrio anguillarum, a serious aquaculture pathogen, we present crystal structures for isochorismatase domains of AngB and VabB, which are required to synthesize siderophore, a critical virulence factor. Both structures are highly similar to known isochorismatases in fold and active site, therefore we conclude inhibitors for isochorismatases can be developed in a common framework. The structural information will improve design of virulence inhibitors against Vibrio anguillarum. We also firstly report that isochorismatase family could bind endogenous metabolite during the hetero-expression process, which is likely nicotinic acid, nicotinamide or pyrazinic acid, based on structural analysis and affinity prediction. Taken together, our results provide precise structural information of isochorismatase domains for antivirulence inhibitor design against Vibrio anguillarum. (C) 2017 Elsevier Inc. All rights reserved.
KeywordVibrio Isochorismatase Unknown Electron Density Antivirulence Inhibitor Aquaculture Disease
DOI10.1016/j.bbrc.2017.06.125
Indexed BySCI
Language英语
WOS IDWOS:000406820600037
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143088
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
First Author Affilication中国科学院海洋研究所
Recommended Citation
GB/T 7714
Du, Jiansen,Deng, Tian,Ma, Qingjun. Crystal structures of the isochorismatase domains from Vibrio anguillarum[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,490(3):827-833.
APA Du, Jiansen,Deng, Tian,&Ma, Qingjun.(2017).Crystal structures of the isochorismatase domains from Vibrio anguillarum.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,490(3),827-833.
MLA Du, Jiansen,et al."Crystal structures of the isochorismatase domains from Vibrio anguillarum".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 490.3(2017):827-833.
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