IOCAS-IR  > 实验海洋生物学重点实验室
Crystal structures of the isochorismatase domains from Vibrio anguillarum
Du, Jiansen1,2; Deng, Tian1,2; Ma, Qingjun1,2
2017-08-26
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷号490期号:3页码:827-833
文章类型Article
摘要Antibiotic resistance is becoming a global threat and overuse of antibiotics in aquaculture disease control worsens the situation. To reduce the risk of drug resistance developed in aquaculture, safer biocontrol programs are needed. Antivirulence therapy, with less chance for developing drug resistance, is a promising approach. To facilitate antivirulence inhibitor design against Vibrio anguillarum, a serious aquaculture pathogen, we present crystal structures for isochorismatase domains of AngB and VabB, which are required to synthesize siderophore, a critical virulence factor. Both structures are highly similar to known isochorismatases in fold and active site, therefore we conclude inhibitors for isochorismatases can be developed in a common framework. The structural information will improve design of virulence inhibitors against Vibrio anguillarum. We also firstly report that isochorismatase family could bind endogenous metabolite during the hetero-expression process, which is likely nicotinic acid, nicotinamide or pyrazinic acid, based on structural analysis and affinity prediction. Taken together, our results provide precise structural information of isochorismatase domains for antivirulence inhibitor design against Vibrio anguillarum. (C) 2017 Elsevier Inc. All rights reserved.
关键词Vibrio Isochorismatase Unknown Electron Density Antivirulence Inhibitor Aquaculture Disease
DOI10.1016/j.bbrc.2017.06.125
收录类别SCI
语种英语
WOS记录号WOS:000406820600037
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143088
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
推荐引用方式
GB/T 7714
Du, Jiansen,Deng, Tian,Ma, Qingjun. Crystal structures of the isochorismatase domains from Vibrio anguillarum[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,490(3):827-833.
APA Du, Jiansen,Deng, Tian,&Ma, Qingjun.(2017).Crystal structures of the isochorismatase domains from Vibrio anguillarum.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,490(3),827-833.
MLA Du, Jiansen,et al."Crystal structures of the isochorismatase domains from Vibrio anguillarum".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 490.3(2017):827-833.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Crystal structures o(2427KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Du, Jiansen]的文章
[Deng, Tian]的文章
[Ma, Qingjun]的文章
百度学术
百度学术中相似的文章
[Du, Jiansen]的文章
[Deng, Tian]的文章
[Ma, Qingjun]的文章
必应学术
必应学术中相似的文章
[Du, Jiansen]的文章
[Deng, Tian]的文章
[Ma, Qingjun]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Crystal structures of the isochorismatase domains from Vibrio anguillarum.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。