IOCAS-IR  > 实验海洋生物学重点实验室
Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis
Liu, Changshui1,2; Ding, Yamei2; Xian, Mo1; Liu, Min1; Liu, Huizhou1; Ma, Qingjun2; Zhao, Guang1
2017
发表期刊CRITICAL REVIEWS IN BIOTECHNOLOGY
卷号37期号:7页码:933-941
文章类型Review
摘要3-Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a biodegradable plastic. To establish a sustainable way to produce these commercially important chemicals and materials, fermentative production of 3HP is widely investigated in recent years. It is reported that 3HP can be produced from several intermediates, such as glycerol, malonyl-CoA, and beta-alanine. Among all these biosynthetic routes, the malonyl-CoA pathway has some distinct advantages, including a broad feedstock spectrum, thermodynamic feasibility, and redox neutrality. To date, this pathway has been successfully constructed in various species including Escherichia coli, yeast and cyanobacteria, and optimized through carbon flux redirection, enzyme screening and engineering, and an increasing supply of energy and cofactors, resulting in significantly enhanced 3HP titer up to 40 g/L. These results show the feasibility of commercial manufacturing of 3HP and its derivatives in the future.
关键词3-hydroxypropionate Malonyl-coa Pathway Metabolic Engineering Acetyl-coa Carboxylase Malonyl-coa Reductase Carbon Flux Enzyme Engineering Supply Of Energy And cOfactor 3hp Tolerance
DOI10.1080/07388551.2016.1272093
收录类别SCI
语种英语
WOS记录号WOS:000407365200009
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143082
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
第一作者单位中国科学院海洋研究所
推荐引用方式
GB/T 7714
Liu, Changshui,Ding, Yamei,Xian, Mo,et al. Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2017,37(7):933-941.
APA Liu, Changshui.,Ding, Yamei.,Xian, Mo.,Liu, Min.,Liu, Huizhou.,...&Zhao, Guang.(2017).Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis.CRITICAL REVIEWS IN BIOTECHNOLOGY,37(7),933-941.
MLA Liu, Changshui,et al."Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis".CRITICAL REVIEWS IN BIOTECHNOLOGY 37.7(2017):933-941.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Malonyl CoA pathway (1463KB)期刊论文出版稿限制开放CC BY-NC-SA浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Changshui]的文章
[Ding, Yamei]的文章
[Xian, Mo]的文章
百度学术
百度学术中相似的文章
[Liu, Changshui]的文章
[Ding, Yamei]的文章
[Xian, Mo]的文章
必应学术
必应学术中相似的文章
[Liu, Changshui]的文章
[Ding, Yamei]的文章
[Xian, Mo]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Malonyl CoA pathway a promising route for 3 hydroxypropionate biosynthesis.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。