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Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin
Wohlgemuth, Viola1; Kindinger, Florian1; Xie, Xiulan2; Wang, Bin-Gui3; Li, Shu-Ming1
2017-11-03
Source PublicationORGANIC LETTERS
Volume19Issue:21Pages:5928-5931
SubtypeArticle
AbstractTwo prenyltransferases from Aspergillus ruber control the echinulin biosynthesis via exceptional sequential prenylations. EchPT1 catalyzes the first prenylation step, leading to preechinulin. The unique EchPT2 attaches, in a consecutive prenylation cascade, up to three dimethylallyl moieties to preechinulin and its dehydro forms neoechinulins A and B, resulting in the formation of at least 23 2- to 4-fold prenylated derivatives. Confirming these products in fungal extracts unravels the unprecedented catalytic relevance of EchPT2 for structural diversity.
DOI10.1021/acs.orglett.7b02926
Indexed BySCI
Language英语
WOS IDWOS:000414723900055
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143069
Collection实验海洋生物学重点实验室
Affiliation1.Philipps Univ Marburg, Inst Pharmazeut Biol & Biotechnol, Robert Koch Str 4, D-35037 Marburg, Germany
2.Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str, D-35032 Marburg, Germany
3.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Wohlgemuth, Viola,Kindinger, Florian,Xie, Xiulan,et al. Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin[J]. ORGANIC LETTERS,2017,19(21):5928-5931.
APA Wohlgemuth, Viola,Kindinger, Florian,Xie, Xiulan,Wang, Bin-Gui,&Li, Shu-Ming.(2017).Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin.ORGANIC LETTERS,19(21),5928-5931.
MLA Wohlgemuth, Viola,et al."Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin".ORGANIC LETTERS 19.21(2017):5928-5931.
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