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Polysaccharides from Sargassum thunbergii: Monthly variations and anti-complement and anti-tumour activities
Jin, Weihua1,2; Liu, Ge2,3; Zhong, Weihong1; Sun, Chaomin2,4; Zhang, Quanbin2,4
2017-12-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号105页码:1526-1531
文章类型Article
摘要Monthly variations of polysaccharides from Sargassum thunbergii and their anti-complement and anti-tumour activities were investigated. It was observed that an increase in fucose and total sugar contents occurred during the growth period (from early April to mid-June), accompanied by a decrease in molar ratios of other monosaccharides to fucose. The highest yields were obtained from early July to early September, which was in accordance with the significant increase in, molar ratio of glucose to fucose and decrease in molar ratio of other monosaccharides to fucose. And the above results suggested that S. Thunbergii synthesized large amount of laminaran, the storage substance of brown algae, during the senescence period. However, sulfate contents were relatively stable in the life cycle of S. thunbergii. These results suggested that S. thunbergii synthesized complex sulfated heteropolysacchairdes during inactive period, while during other periods, it synthesized more sulfated galactofucan. All polysaccharides showed anti-complement activity, suggesting that the harvesting time did not influence the anti-complement activities. In the anti-tumour assay in vitro, the polysaccharides taken during the senescence period had much lower anti-tumour activity, suggesting that fucoidan, but not laminaran, determined the anti-tumour activities. Therefore, polysaccharides from S. thunbergii might have great potential in anti-complement and anti-tumour application. (C) 2017 Elsevier B.V. All rights reserved.
关键词Sargassum Thunbergii Anti-complement Activities Anti-tumour Activities
DOI10.1016/j.ijbiomac.2017.05.104
收录类别SCI
语种英语
WOS记录号WOS:000415779800021
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/143064
专题实验海洋生物学重点实验室
作者单位1.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
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Jin, Weihua,Liu, Ge,Zhong, Weihong,et al. Polysaccharides from Sargassum thunbergii: Monthly variations and anti-complement and anti-tumour activities[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,105:1526-1531.
APA Jin, Weihua,Liu, Ge,Zhong, Weihong,Sun, Chaomin,&Zhang, Quanbin.(2017).Polysaccharides from Sargassum thunbergii: Monthly variations and anti-complement and anti-tumour activities.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,105,1526-1531.
MLA Jin, Weihua,et al."Polysaccharides from Sargassum thunbergii: Monthly variations and anti-complement and anti-tumour activities".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 105(2017):1526-1531.
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