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Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-beta 1 or FGF-2
Li, Xinpeng1,2,3; Li, Xiaohong5; Zhang, Quanbin1,2; Zhao, Tingting4
2017-12-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume105Pages:1482-1490
SubtypeArticle
AbstractWe investigated the renal protective effects of low molecular weight fucoidan (LMWF) and its two fractions (F0.5 and F1.0), which were extracted from Laminaria japonica, on the epithelial-mesenchymal transition (EMT) induced by transforming growth factor beta 1 (TGF-beta 1) and fibroblast growth factor 2 (FGF-2) in HK-2 human renal proximal tubular cells. Cell morphology and EMT markers (fibronectin and alpha-smooth muscle actin) demonstrated that cells treated with TGF-beta 1 or FGF-2 developed EMT to a significant extent. Treatment with LMWF or its fractions markedly attenuated the EMT and decreased expression of the EMT markers. The F1.0 fraction, the sulfated fucan fraction, was found to be the main active component of LMWF, and heparanase (HPSE) was a key factor in renal tubular epithelial trans differentiation. The F1.0 fraction inhibited elevated HPSE and matrix metallopeptidase 9 expression, thereby attenuating the progress of EMT. (C) 2017 Elsevier B.V. All rights reserved.
KeywordLow Molecular Weight Fucoidan Renal Fibrosis Epithelial-mesenchymal Transition
DOI10.1016/j.ijbiomac.2017.06.058
Indexed BySCI
Language英语
WOS IDWOS:000415779800016
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143063
Collection海洋生物技术研发中心
实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.China Japan Friendship Hosp, Inst Clin Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, Beijing, Peoples R China
5.Qingdao Municipal Hosp, Qingdao, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Xinpeng,Li, Xiaohong,Zhang, Quanbin,et al. Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-beta 1 or FGF-2[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,105:1482-1490.
APA Li, Xinpeng,Li, Xiaohong,Zhang, Quanbin,&Zhao, Tingting.(2017).Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-beta 1 or FGF-2.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,105,1482-1490.
MLA Li, Xinpeng,et al."Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-beta 1 or FGF-2".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 105(2017):1482-1490.
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