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A teleost CD46 is involved in the regulation of complement activation and pathogen infection
Li, Mo-fei1,2; Sui, Zhi-hai1,3; Sun, Li1,2
2017-11-03
Source PublicationSCIENTIFIC REPORTS
Volume7
SubtypeArticle
AbstractIn mammals, CD46 is involved in the inactivation of complement by factor I (FI). In teleost, study on the function of CD46 is very limited. In this study, we examined the immunological property of a CD46 molecule (CsCD46) from tongue sole, a teleost species with important economic value. We found that recombinant CsCD46 (rCsCD46) interacted with FI and inhibited complement activation in an FI-dependent manner. rCsCD46 also interacted with bacterial pathogens via a different mechanism to that responsible for the FI interaction, involving different rCsCD46 sites. Cellular study showed that CsCD46 was expressed on peripheral blood leukocytes (PBL) and protected the cells against the killing effect of complement. When the CsCD46 on PBL was blocked by antibody before incubation of the cells with bacterial pathogens, cellular infection was significantly reduced. Consistently, when tongue sole were infected with bacterial pathogens in the presence of rCsCD46, tissue dissemination and survival of the pathogens were significantly inhibited. These results provide the first evidence to indicate that CD46 in teleosts negatively regulates complement activation via FI and protects host cells from complement-induced damage, and that CD46 is required for optimal bacterial infection probably by serving as a receptor for the bacteria.
DOI10.1038/s41598-017-15124-y
Indexed BySCI
Language英语
WOS IDWOS:000414414700001
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143051
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Mo-fei,Sui, Zhi-hai,Sun, Li. A teleost CD46 is involved in the regulation of complement activation and pathogen infection[J]. SCIENTIFIC REPORTS,2017,7.
APA Li, Mo-fei,Sui, Zhi-hai,&Sun, Li.(2017).A teleost CD46 is involved in the regulation of complement activation and pathogen infection.SCIENTIFIC REPORTS,7.
MLA Li, Mo-fei,et al."A teleost CD46 is involved in the regulation of complement activation and pathogen infection".SCIENTIFIC REPORTS 7(2017).
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