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The sea cucumber genome provides insights into morphological evolution and visceral regeneration
Zhang, Xiaojun1,2; Sun, Lina1,2; Yuan, Jianbo1,2; Sun, Yamin3; Gao, Yi1,2; Zhang, Libin1,2; Li, Shihao1,2; Dai, Hui3; Hamel, Jean-Francois4; Liu, Chengzhang1,2; Yu, Yang1,2; Liu, Shilin1,2; Lin, Wenchao3; Guo, Kaimin3; Jin, Songjun1,2; Xu, Peng5; Storey, Kenneth B.6; Huan, Pin1,2; Zhang, Tao1,2; Zhou, Yi1,2; Zhang, Jiquan1,2; Lin, Chenggang1,2; Li, Xiaoni1,7; Xing, Lili1,7; Huo, Da1,7; Sun, Mingzhe1,7; Wang, Lei8; Mercier, Annie9; Li, Fuhua1,2; Yang, Hongsheng1,2; Xiang, Jianhai1,2
2017-10-01
Source PublicationPLOS BIOLOGY
Volume15Issue:10
SubtypeArticle
AbstractApart from sharing common ancestry with chordates, sea cucumbers exhibit a unique morphology and exceptional regenerative capacity. Here we present the complete genome sequence of an economically important sea cucumber, A. japonicus, generated using Illumina and PacBio platforms, to achieve an assembly of approximately 805 Mb (contig N50 of 190 Kb and scaffold N50 of 486 Kb), with 30,350 protein-coding genes and high continuity. We used this resource to explore key genetic mechanisms behind the unique biological characters of sea cucumbers. Phylogenetic and comparative genomic analyses revealed the presence of marker genes associated with notochord and gill slits, suggesting that these chordate features were present in ancestral echinoderms. The unique shape and weak mineralization of the sea cucumber adult body were also preliminarily explained by the contraction of biomineralization genes. Genome, transcriptome, and proteome analyses of organ regrowth after induced evisceration provided insight into the molecular underpinnings of visceral regeneration, including a specific tandem-duplicated prostatic secretory protein of 94 amino acids (PSP94)-like gene family and a significantly expanded fibrinogen-related protein (FREP) gene family. This high-quality genome resource will provide a useful framework for future research into biological processes and evolution in deuterostomes, including remarkable regenerative abilities that could have medical applications. Moreover, the multiomics data will be of prime value for commercial sea cucumber breeding programs.
DOI10.1371/journal.pbio.2003790
Indexed BySCI
Language英语
WOS IDWOS:000414060400012
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143042
Collection实验海洋生物学重点实验室
海洋生态与环境科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol & Marine Ecol & Environm, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol & Marine Ecol & Envi, Qingdao, Peoples R China
3.Tianjin Biochip Corp, Tianjin, Peoples R China
4.SEVE, Portugal Cove St Philips, NF, Canada
5.Xiamen Univ, Coll Ocean & Earth Sci, Xiamen, Peoples R China
6.Carleton Univ, Dept Biol, Ottawa, ON, Canada
7.Univ Chinese Acad Sci, Beijing, Peoples R China
8.Nankai Univ, Coll Life Sci, Tianjin, Peoples R China
9.Mem Univ, Dept Ocean Sci, St John, NF, Canada
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Xiaojun,Sun, Lina,Yuan, Jianbo,et al. The sea cucumber genome provides insights into morphological evolution and visceral regeneration[J]. PLOS BIOLOGY,2017,15(10).
APA Zhang, Xiaojun.,Sun, Lina.,Yuan, Jianbo.,Sun, Yamin.,Gao, Yi.,...&Xiang, Jianhai.(2017).The sea cucumber genome provides insights into morphological evolution and visceral regeneration.PLOS BIOLOGY,15(10).
MLA Zhang, Xiaojun,et al."The sea cucumber genome provides insights into morphological evolution and visceral regeneration".PLOS BIOLOGY 15.10(2017).
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