IOCAS-IR  > 海洋生态与环境科学重点实验室
Carbohydrate and amino acids metabolic response to heat stress in the intestine of the sea cucumber Apostichopus japonicus
Xu, Dongxue1; Zhou, Shun1; Yang, Hongsheng2
2017-12-01
Source PublicationAQUACULTURE RESEARCH
Volume48Issue:12Pages:5883-5891
SubtypeArticle
AbstractThe sea cucumber Apostichopus japonicus is an economic species mainly distributed along the coast of northern China, south-eastern Russia, Japan, Republic of Korea and Democratic People's Republic of Korea. Aquaculture industry of A.japonicus has been facing severe challenge of high temperature. In this study, we studied the mRNA expression profiles of eight key metabolic enzymes involved in carbohydrate and amino acids metabolism in A.japonicus under heat stress. The expression of hexokinase, pyruvate kinase and malate dehydrogenase showed downregulated response to heat stress, while the expression of glutamate dehydrogenase, alanine transaminase and branched-chain aminotransferase showed upregulated response. In addition, the expression of lactate dehydrogenase and glutamate synthase showed no significant difference. We also applied H-1 NMR-based metabolomics to investigate metabolic changes in the intestine tissue of A. japonicus under heat stress, the results of which revealed nine increased and 10 decreased metabolites in the heat stress group. These response genes and metabolites have potential to become markers for identifying severity of heat stress. More importantly, our findings suggest significant links between gene expression and metabolites changing, highlighting regulation networks of carbohydrate and amino acid metabolism in heat-stressed A. japonicus.
KeywordApostichopus Japonicus Carbohydrate And Amino Acid Mechanism Heat Stress Metabolic Enzymes Metabolomics
DOI10.1111/are.13411
Indexed BySCI
Language英语
WOS IDWOS:000414941000019
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/143038
Collection海洋生态与环境科学重点实验室
Affiliation1.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
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Xu, Dongxue,Zhou, Shun,Yang, Hongsheng. Carbohydrate and amino acids metabolic response to heat stress in the intestine of the sea cucumber Apostichopus japonicus[J]. AQUACULTURE RESEARCH,2017,48(12):5883-5891.
APA Xu, Dongxue,Zhou, Shun,&Yang, Hongsheng.(2017).Carbohydrate and amino acids metabolic response to heat stress in the intestine of the sea cucumber Apostichopus japonicus.AQUACULTURE RESEARCH,48(12),5883-5891.
MLA Xu, Dongxue,et al."Carbohydrate and amino acids metabolic response to heat stress in the intestine of the sea cucumber Apostichopus japonicus".AQUACULTURE RESEARCH 48.12(2017):5883-5891.
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