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Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation
Li, Kecheng1,2; Xing, Ronge1; Liu, Song1; Qin, Yukun1; Li, Pengcheng1
2017
发表期刊BIOMED RESEARCH INTERNATIONAL
文章类型Article
摘要Chitohexaose has attracted wide interest due to its special bioactivities and these potential activities are significantly related to N-acetylation. Herein, six chitohexaose fractions with different degrees of acetylation were prepared by selective N-acetylation and ion-exchange chromatography and further analyzed by ESI/MS. It is revealed that all the six N-acetylated chitohexaoses were of single molecular weight, the molecular weights of which were exactly assigned to 1026.44 Da, 1068.44 Da, 1110.48 Da, 1152.48 Da, 1194.49 Da, and 1236.48 Da, respectively. These results suggested that the six prepared N-acetylated chitohexaoses were N-acetylchitohexaose (D5A1), di-N-acetylchitohexaose (D4A2), tri-N-acetylchitohexaose (D3A3), tetra-N-acetylchitohexaose (D2A4), penta-N-acetylchitohexaose (D1A5), and hexa-N-acetylchitohexaose (A6), respectively, which are of great significance to screen their bioactivities and discover well-defined chitooligosaccharide molecules as potential drugs.
DOI10.1155/2017/2486515
收录类别SCI
语种英语
WOS记录号WOS:000402657100001
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文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/137099
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.IOCAS, Nantong Marine Sci & Technol R&D Ctr, Nantong 226006, Jiangsu, Peoples R China
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GB/T 7714
Li, Kecheng,Xing, Ronge,Liu, Song,et al. Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation[J]. BIOMED RESEARCH INTERNATIONAL,2017.
APA Li, Kecheng,Xing, Ronge,Liu, Song,Qin, Yukun,&Li, Pengcheng.(2017).Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation.BIOMED RESEARCH INTERNATIONAL.
MLA Li, Kecheng,et al."Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation".BIOMED RESEARCH INTERNATIONAL (2017).
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