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Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans
Zhang, Enhui1,2,3; Xing, Ronge1,3; Liu, Song1,3; Li, Kecheng1,3; Qin, Yukun1,3; Yu, Huahua1,3; Li, Pengcheng1,3
2017-08-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume101Pages:1012-1018
SubtypeArticle
AbstractIn this study, three different carboxymethyl chitosans (CMCs), namely O-carboxymethyl chitosan (OC), N-carboxymethyl chitosan (NC) and N,O-carboxymethyl chitosan (NOC), were prepared as nano-carriers for an anti-tumor drug, docetaxel (DCT). Three CMCs were fabricated into drug-loading nanoparticles under different preparing conditions respectively. A series of characterization parameters were determined including drug loading capacity (DC), entrapment efficiency (EE), particle size distribution, zeta potential, and morphology, which were used to find the optimized preparing condition for three kinds of nanoparticles (NPs). Furthermore, the in vitro drug release profiles of all the three kinds of nanoparticles showed a sustained release behavior and the release rate of OC-NPs was the fastest. Moreover, compared with NC-NPs and NOC-NPs, OC-NPs exhibited more cellular accumulation in the human gastric carcinoma cells (SGC 7901) as quantitatively determined by the flow cytometry and also much stronger cytotoxicity against these cells. Accordingly, our results showed that drug-loaded nanoparticles formed by different CMCs have dissimilar physiochemical characteristics which subsequently influence their" therapeutic effects. We suggest that OC-based nanoparticle is a more desirable anti-tumor drug delivery system than NC-NP and NOC-NP. (C) 2017 Elsevier B.V. All rights reserved.
KeywordCarboxymethyl Chitosan Nanoparticle Anti-tumor
DOI10.1016/j.ijbiomac.2017.03.195
Indexed BySCI
Language英语
WOS IDWOS:000404491300110
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/137032
Collection海洋生物技术研发中心
实验海洋生物学重点实验室
海洋环境工程技术研究发展中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Enhui,Xing, Ronge,Liu, Song,et al. Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,101:1012-1018.
APA Zhang, Enhui.,Xing, Ronge.,Liu, Song.,Li, Kecheng.,Qin, Yukun.,...&Li, Pengcheng.(2017).Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,101,1012-1018.
MLA Zhang, Enhui,et al."Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 101(2017):1012-1018.
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