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Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans
Zhang, Enhui1,2,3; Xing, Ronge1,3; Liu, Song1,3; Li, Kecheng1,3; Qin, Yukun1,3; Yu, Huahua1,3; Li, Pengcheng1,3
2017-08-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号101页码:1012-1018
文章类型Article
摘要In this study, three different carboxymethyl chitosans (CMCs), namely O-carboxymethyl chitosan (OC), N-carboxymethyl chitosan (NC) and N,O-carboxymethyl chitosan (NOC), were prepared as nano-carriers for an anti-tumor drug, docetaxel (DCT). Three CMCs were fabricated into drug-loading nanoparticles under different preparing conditions respectively. A series of characterization parameters were determined including drug loading capacity (DC), entrapment efficiency (EE), particle size distribution, zeta potential, and morphology, which were used to find the optimized preparing condition for three kinds of nanoparticles (NPs). Furthermore, the in vitro drug release profiles of all the three kinds of nanoparticles showed a sustained release behavior and the release rate of OC-NPs was the fastest. Moreover, compared with NC-NPs and NOC-NPs, OC-NPs exhibited more cellular accumulation in the human gastric carcinoma cells (SGC 7901) as quantitatively determined by the flow cytometry and also much stronger cytotoxicity against these cells. Accordingly, our results showed that drug-loaded nanoparticles formed by different CMCs have dissimilar physiochemical characteristics which subsequently influence their" therapeutic effects. We suggest that OC-based nanoparticle is a more desirable anti-tumor drug delivery system than NC-NP and NOC-NP. (C) 2017 Elsevier B.V. All rights reserved.
关键词Carboxymethyl Chitosan Nanoparticle Anti-tumor
DOI10.1016/j.ijbiomac.2017.03.195
收录类别SCI
语种英语
WOS记录号WOS:000404491300110
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/137032
专题海洋生物技术研发中心
实验海洋生物学重点实验室
海洋环境工程技术研究发展中心
作者单位1.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
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GB/T 7714
Zhang, Enhui,Xing, Ronge,Liu, Song,et al. Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,101:1012-1018.
APA Zhang, Enhui.,Xing, Ronge.,Liu, Song.,Li, Kecheng.,Qin, Yukun.,...&Li, Pengcheng.(2017).Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,101,1012-1018.
MLA Zhang, Enhui,et al."Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 101(2017):1012-1018.
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