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iTRAQ reveals proteomic changes during intestine regeneration in the sea cucumber Apostichopus japonicus
Sun, Lina1; Xu, Dongxue3; Xu, Qinzeng4; Sun, Jingchun1; Xing, Lili1,2; Zhang, Libin1; Yang, Hongsheng1
2017-06-01
发表期刊COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
卷号22页码:39-49
文章类型Article
摘要Sea cucumbers have a striking capacity to regenerate most of their viscera after evisceration, which has drawn the interest of many researchers. In this study, the isobaric tag for relative and absolute quantitation (iTRAQ) was utilized to investigate protein abundance changes during intestine regeneration in sea cucumbers. A total of 4073 proteins were identified, and 2321 proteins exhibited significantly differential expressions, with 1100 upregulated and 1221 downregulated proteins. Our results suggest that intestine regeneration constitutes a complex life activity regulated by the cooperation of various biological processes, including cytoskeletal changes, extracellular matrix (ECM) remodeling and ECM-receptor interactions, protein synthesis, signal recognition and transduction, energy production and conversion, and substance transport and metabolism. Additionally, real-time PCR showed mRNA expression of differentially expressed genes correlated positively with their protein levels. Our results provided a basis for studying the regulatory mechanisms associated with sea cucumber regeneration. (C) 2017 Elsevier Inc All rights reserved.
关键词Sea Cucumber Intestine Regeneration Itraq Proteomics
DOI10.1016/j.cbd.2017.02.004
收录类别SCI
语种英语
WOS记录号WOS:000402220500005
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136873
专题海洋生态与环境科学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Qingdao Agr Univ, Marine Sci & Engn Coll, Qingdao, Peoples R China
4.State Ocean Adm, Inst Oceanog 1, Key Lab Marine Ecol & Environm Sci & Engn, Qingdao, Peoples R China
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Sun, Lina,Xu, Dongxue,Xu, Qinzeng,et al. iTRAQ reveals proteomic changes during intestine regeneration in the sea cucumber Apostichopus japonicus[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2017,22:39-49.
APA Sun, Lina.,Xu, Dongxue.,Xu, Qinzeng.,Sun, Jingchun.,Xing, Lili.,...&Yang, Hongsheng.(2017).iTRAQ reveals proteomic changes during intestine regeneration in the sea cucumber Apostichopus japonicus.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,22,39-49.
MLA Sun, Lina,et al."iTRAQ reveals proteomic changes during intestine regeneration in the sea cucumber Apostichopus japonicus".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 22(2017):39-49.
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