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MARS: A protein family involved in the formation of vertical skeletal elements
Abehsera, Shai1,2; Peles, Shani1; Tynyakov, Jenny3; Bentov, Shmuel2; Aflalo, Eliahu D.1,2; Li, Shihao4; Li, Fuhua4; Xiang, Jianhai4; Sagi, Amir1,2
2017-05-01
发表期刊JOURNAL OF STRUCTURAL BIOLOGY
卷号198期号:2页码:92-102
文章类型Article
摘要Vertical organizations of skeletal elements are found in various vertebrate teeth and invertebrate exoskeletons. The molecular mechanism behind the development of such structural organizations is poorly known, although it is generally held that organic matrix proteins play an essential role. While most crustacean cuticular organizations exhibit horizontal chitinous layering, a typical vertical organization is found towards the surface of the teeth in the mandibles of the crayfish Cherax quadricarinatus. Candidate genes encoding for mandible-forming structural proteins were mined in C quadricarinatus molt-related transcriptomic libraries by using a binary patterning approach. A new protein family, termed the Mandible Alanine Rich Structural (MARS) protein family, with a modular sequence design predicted to form fibers, was found. Investigations of spatial and temporal expression of the different MARS genes suggested specific expression in the mandibular teeth-forming epithelium, particularly during the formation of the chitinous vertical organization. MARS loss-of-function RNAi experiments resulted in the collapse of the organization of the chitin fibers oriented vertically to the surface of the crayfish mandibular incisor tooth. A general search of transcriptomic libraries suggested conservation of MARS proteins across a wide array of crustaceans. Our results provide a first look into the molecular mechanism used to build the complex crustacean mandible and into the specialized vertical structural solution that has evolved in skeletal elements. (C) 2017 Elsevier Inc. All rights reserved.
关键词Crustacean Mandible Chitin Fibers Mars Proteins Structural Proteins Tooth Structure Vertical Elements
DOI10.1016/j.jsb.2017.04.003
收录类别SCI
语种英语
WOS记录号WOS:000402026300004
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136863
专题实验海洋生物学重点实验室
作者单位1.Ben Gurion Univ Negev, Dept Life Sci, Beer Sheva, Israel
2.Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, Beer Sheva, Israel
3.Tel Aviv Univ, Dept Zool, Interuniv Inst Marine Sci, Steinitz Marine Biol Lab, Tel Aviv, Israel
4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
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Abehsera, Shai,Peles, Shani,Tynyakov, Jenny,et al. MARS: A protein family involved in the formation of vertical skeletal elements[J]. JOURNAL OF STRUCTURAL BIOLOGY,2017,198(2):92-102.
APA Abehsera, Shai.,Peles, Shani.,Tynyakov, Jenny.,Bentov, Shmuel.,Aflalo, Eliahu D..,...&Sagi, Amir.(2017).MARS: A protein family involved in the formation of vertical skeletal elements.JOURNAL OF STRUCTURAL BIOLOGY,198(2),92-102.
MLA Abehsera, Shai,et al."MARS: A protein family involved in the formation of vertical skeletal elements".JOURNAL OF STRUCTURAL BIOLOGY 198.2(2017):92-102.
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