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MARS: A protein family involved in the formation of vertical skeletal elements
Abehsera, Shai1,2; Peles, Shani1; Tynyakov, Jenny3; Bentov, Shmuel2; Aflalo, Eliahu D.1,2; Li, Shihao4; Li, Fuhua4; Xiang, Jianhai4; Sagi, Amir1,2
2017-05-01
Source PublicationJOURNAL OF STRUCTURAL BIOLOGY
Volume198Issue:2Pages:92-102
SubtypeArticle
AbstractVertical organizations of skeletal elements are found in various vertebrate teeth and invertebrate exoskeletons. The molecular mechanism behind the development of such structural organizations is poorly known, although it is generally held that organic matrix proteins play an essential role. While most crustacean cuticular organizations exhibit horizontal chitinous layering, a typical vertical organization is found towards the surface of the teeth in the mandibles of the crayfish Cherax quadricarinatus. Candidate genes encoding for mandible-forming structural proteins were mined in C quadricarinatus molt-related transcriptomic libraries by using a binary patterning approach. A new protein family, termed the Mandible Alanine Rich Structural (MARS) protein family, with a modular sequence design predicted to form fibers, was found. Investigations of spatial and temporal expression of the different MARS genes suggested specific expression in the mandibular teeth-forming epithelium, particularly during the formation of the chitinous vertical organization. MARS loss-of-function RNAi experiments resulted in the collapse of the organization of the chitin fibers oriented vertically to the surface of the crayfish mandibular incisor tooth. A general search of transcriptomic libraries suggested conservation of MARS proteins across a wide array of crustaceans. Our results provide a first look into the molecular mechanism used to build the complex crustacean mandible and into the specialized vertical structural solution that has evolved in skeletal elements. (C) 2017 Elsevier Inc. All rights reserved.
KeywordCrustacean Mandible Chitin Fibers Mars Proteins Structural Proteins Tooth Structure Vertical Elements
DOI10.1016/j.jsb.2017.04.003
Indexed BySCI
Language英语
WOS IDWOS:000402026300004
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136863
Collection实验海洋生物学重点实验室
Affiliation1.Ben Gurion Univ Negev, Dept Life Sci, Beer Sheva, Israel
2.Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, Beer Sheva, Israel
3.Tel Aviv Univ, Dept Zool, Interuniv Inst Marine Sci, Steinitz Marine Biol Lab, Tel Aviv, Israel
4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Abehsera, Shai,Peles, Shani,Tynyakov, Jenny,et al. MARS: A protein family involved in the formation of vertical skeletal elements[J]. JOURNAL OF STRUCTURAL BIOLOGY,2017,198(2):92-102.
APA Abehsera, Shai.,Peles, Shani.,Tynyakov, Jenny.,Bentov, Shmuel.,Aflalo, Eliahu D..,...&Sagi, Amir.(2017).MARS: A protein family involved in the formation of vertical skeletal elements.JOURNAL OF STRUCTURAL BIOLOGY,198(2),92-102.
MLA Abehsera, Shai,et al."MARS: A protein family involved in the formation of vertical skeletal elements".JOURNAL OF STRUCTURAL BIOLOGY 198.2(2017):92-102.
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