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Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)
Meng, Lingjie1,2; Du, Yishuai1; Liu, Pengfei1,2; Li, Xian1; Liu, Ying3
2017-05-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
Volume64Pages:260-269
SubtypeArticle
AbstractQuorum sensing is a bacterial density dependent communication system, which regarded to regulate cooperative behaviors of community and mediated by extracellular signal molecules named autoinducers (Al). Among various signals, autoinducer-2 (AI-2) is believed to be the messengers inter species and produced by LuxS. For Aeromonas salmonicida (A. salmonicida), an opportunistic pathogen to many cold-water teleost, little information has been known about the function of AI-2 and LuxS. Therefore, our aim was to preliminarily clarify the function of LuxS in A. salmonicida. The consequences demonstrated that wild type A. salmonicida exhibited Al-2 activity and luxS defective mutant strain fail to produce Al-2 signals. Furthermore, it was suggested that luxS deficiency could impact bacterial morphology, surface properties and virulence dramatically. Challenge experiment showed a tendency that immune factors expressed earlier when Atlantic salmon was infected with AluxS strain. Overall, we hypothesis that Al-2 quorum sensing could regulate the expression of A-layer protein coding gene vapA, and then influence bacterial survival ability when suffered from attack of the host immune system. Though additional studies are warranted, our study will supply a new thinking to control the damage caused by A. salmonicida. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordQuorum Sensing Ai-2 Luxs Aeromonas Salmonicida Virulence Surface Property A-layer Innate Immnuity Salmo Solar l
DOI10.1016/j.fsi.2017.03.009
Indexed BySCI
Language英语
WOS IDWOS:000401217900028
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Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136852
Collection海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Dalian Ocean Univ, Dalian 116023, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Meng, Lingjie,Du, Yishuai,Liu, Pengfei,et al. Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)[J]. FISH & SHELLFISH IMMUNOLOGY,2017,64:260-269.
APA Meng, Lingjie,Du, Yishuai,Liu, Pengfei,Li, Xian,&Liu, Ying.(2017).Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L).FISH & SHELLFISH IMMUNOLOGY,64,260-269.
MLA Meng, Lingjie,et al."Involvement of LuxS in Aeromonas salmonicida metabolism, virulence and infection in Atlantic salmon (Salmo salar L)".FISH & SHELLFISH IMMUNOLOGY 64(2017):260-269.
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