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Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus
Sun, Lina1; Sun, Jingchun1; Xu, Qinzeng3; Li, Xiaoni1,2; Zhang, Libin1; Yang, Hongsheng1
2017-06-01
Source PublicationCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
Volume22Pages:32-38
SubtypeArticle
AbstractSea cucumbers are excellent models for studying organ regeneration due to their striking capacity to regenerate most of their viscera after evisceration. In this study, we applied NMR-based metabolomics to determine the metabolite changes that occur during the process of intestine regeneration in sea cucumbers. Partial least-squares discriminant analysis showed that there was significant differences in metabolism between regenerative intestines at 3, 7, and 14 days post evisceration (dpe) and normal intestines. Changes in the concentration of 13 metabolites related to regeneration were observed and analyzed. These metabolites included leucine, isoleucine, valine, arginine, glutamate, hypotaurine, dimethylamine, N,N-dimethylglycine, betaine, taurine, inosine, homarine, and histidine. Three important genes (betaine-aldehyde dehydrogenase, betaine-homocysteine S-methyltransferase 1, and dimethylglycine dehydrogenase) were differentially expressed to regulate the levels of betaine and N,N-dimethylglycine during intestine regeneration. These results provide an important basis for studying regenerative mechanisms and developing regenerative matrixes. (C) 2017 Elsevier Inc. All rights reserved.
KeywordSea Cucumber Metabolic Responses Gene Expression Intestine Regeneration
DOI10.1016/j.cbd.2017.02.003
Indexed BySCI
Language英语
WOS IDWOS:000402220500004
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136847
Collection海洋生态与环境科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.State Ocean Adm, Inst Oceanog 1, Key Lab Marine Ecol & Environm Sci & Engn, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sun, Lina,Sun, Jingchun,Xu, Qinzeng,et al. Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2017,22:32-38.
APA Sun, Lina,Sun, Jingchun,Xu, Qinzeng,Li, Xiaoni,Zhang, Libin,&Yang, Hongsheng.(2017).Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,22,32-38.
MLA Sun, Lina,et al."Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 22(2017):32-38.
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