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Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy
Xu, Yingjie1,2,3; Zhang, Quanbin1,4,5; Luo, Dali6; Wang, Jing1,4; Duan, Delin1,4,5
2017-02-01
Source PublicationJOURNAL OF APPLIED PHYCOLOGY
Volume29Issue:1Pages:531-542
SubtypeArticle
AbstractDiabetic nephropathy (DN) is a type of serious microangiopathy that is caused by diabetes mellitus (DM). It is the most common cause of chronic renal failure and end-stage renal disease, and it severely affects patients' quality of life. This work aims to study the effect and mechanism of low molecular weight fucoidan (LMWF) on streptozotocin (STZ)-induced DN. The experimental results showed that LMWF prevented weight loss in DN rats, significantly reduced the levels of biochemical indexes in blood and urine samples, and also lowered hyaluronic acid (HA) levels and advanced glycosylation end product-specific receptor (AGER) levels in DN rats. LMWF maintained the structural integrity of glomerular basement membrane (GBM) and glomerulus, improved the glomerular filtration function, protected glycosaminoglycan from abnormal degrading, prevented advanced glycosylation end product (AGE) from being generated and accumulating, and also alleviated inflammatory response in DN rats. LMWF could obviously ameliorate and slow the development and progression of DN in rats.
KeywordFucoidan Diabetic Nephropathy Hspg Glycosaminoglycan Inflammatory Cytokines
DOI10.1007/s10811-016-0942-0
Indexed BySCI
Language英语
WOS IDWOS:000396344800047
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136791
Collection实验海洋生物学重点实验室
海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Univ, Inst Cerebrovasc Dis, Affiliated Hosp, Qingdao 266003, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
5.State Key Lab Seaweed Bioact Subst, Qingdao, Peoples R China
6.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China
Recommended Citation
GB/T 7714
Xu, Yingjie,Zhang, Quanbin,Luo, Dali,et al. Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy[J]. JOURNAL OF APPLIED PHYCOLOGY,2017,29(1):531-542.
APA Xu, Yingjie,Zhang, Quanbin,Luo, Dali,Wang, Jing,&Duan, Delin.(2017).Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy.JOURNAL OF APPLIED PHYCOLOGY,29(1),531-542.
MLA Xu, Yingjie,et al."Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy".JOURNAL OF APPLIED PHYCOLOGY 29.1(2017):531-542.
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