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Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy
Xu, Yingjie1,2,3; Zhang, Quanbin1,4,5; Luo, Dali6; Wang, Jing1,4; Duan, Delin1,4,5
2017-02-01
发表期刊JOURNAL OF APPLIED PHYCOLOGY
卷号29期号:1页码:531-542
文章类型Article
摘要Diabetic nephropathy (DN) is a type of serious microangiopathy that is caused by diabetes mellitus (DM). It is the most common cause of chronic renal failure and end-stage renal disease, and it severely affects patients' quality of life. This work aims to study the effect and mechanism of low molecular weight fucoidan (LMWF) on streptozotocin (STZ)-induced DN. The experimental results showed that LMWF prevented weight loss in DN rats, significantly reduced the levels of biochemical indexes in blood and urine samples, and also lowered hyaluronic acid (HA) levels and advanced glycosylation end product-specific receptor (AGER) levels in DN rats. LMWF maintained the structural integrity of glomerular basement membrane (GBM) and glomerulus, improved the glomerular filtration function, protected glycosaminoglycan from abnormal degrading, prevented advanced glycosylation end product (AGE) from being generated and accumulating, and also alleviated inflammatory response in DN rats. LMWF could obviously ameliorate and slow the development and progression of DN in rats.
关键词Fucoidan Diabetic Nephropathy Hspg Glycosaminoglycan Inflammatory Cytokines
DOI10.1007/s10811-016-0942-0
收录类别SCI
语种英语
WOS记录号WOS:000396344800047
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文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136791
专题实验海洋生物学重点实验室
海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Univ, Inst Cerebrovasc Dis, Affiliated Hosp, Qingdao 266003, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
5.State Key Lab Seaweed Bioact Subst, Qingdao, Peoples R China
6.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China
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Xu, Yingjie,Zhang, Quanbin,Luo, Dali,et al. Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy[J]. JOURNAL OF APPLIED PHYCOLOGY,2017,29(1):531-542.
APA Xu, Yingjie,Zhang, Quanbin,Luo, Dali,Wang, Jing,&Duan, Delin.(2017).Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy.JOURNAL OF APPLIED PHYCOLOGY,29(1),531-542.
MLA Xu, Yingjie,et al."Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy".JOURNAL OF APPLIED PHYCOLOGY 29.1(2017):531-542.
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