IOCAS-IR  > 实验海洋生物学重点实验室
Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse
Zhao, Jingli1,2; Li, Shuling3; Wang, Lijuan4; Jiang, Li2; Yang, Runqing1; Cui, Yuehua5,6
2017-03-24
发表期刊SCIENTIFIC REPORTS
卷号7
文章类型Article
摘要Genomic imprinting underlying growth and development traits has been recognized, with a focus on the form of absolute or pure growth. However, little is known about the effect of genomic imprinting on relative growth. In this study, we proposed a random regression model to estimate genome-wide imprinting effects on the relative growth of multiple tissues and organs to body weight in mice. Joint static allometry scaling equation as sub-model is nested within the genetic effects of markers and polygenic effects caused by a pedigree. Both chromosome-wide and genome-wide statistical tests were conducted to identify imprinted quantitative trait nucleotides (QTNs) associated with relative growth of individual tissues and organs to body weight. Real data analysis showed that three of six analysed tissues and organs are significantly associated with body weight in terms of phenotypic relative growth. At the chromosome-wide level, a total 122 QTNs were associated with allometries of kidney, spleen and liver weights to body weight, 36 of which were imprinted with different imprinting fashions. Further, only two imprinted QTNs responsible for relative growth of spleen and liver were verified by genome-wide test. Our approach provides a general framework for statistical inference of genomic imprinting underlying allometry scaling in animals.
DOI10.1038/srep45191
收录类别SCI
语种英语
WOS记录号WOS:000397381200001
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136764
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Fishery Sci, Res Ctr Aquat Biotechnol, Minist Agr, Key Lab Aquat Genom, Beijing 100141, Peoples R China
2.Nanjing Agr Univ, Wuxi Fisheries Coll, Nanjing 214128, Peoples R China
3.Northeast Agr Univ, Coll Life Sci, Harbin 150030, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
5.Michigan State Univ, Dept Stat & Probabil, E Lansing, MI 48864 USA
6.Shanxi Med Univ, Sch Publ Hlth, Div Hlth Stat, Taiyuan 030001, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Jingli,Li, Shuling,Wang, Lijuan,et al. Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse[J]. SCIENTIFIC REPORTS,2017,7.
APA Zhao, Jingli,Li, Shuling,Wang, Lijuan,Jiang, Li,Yang, Runqing,&Cui, Yuehua.(2017).Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse.SCIENTIFIC REPORTS,7.
MLA Zhao, Jingli,et al."Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse".SCIENTIFIC REPORTS 7(2017).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Genome-wide random r(664KB)期刊论文出版稿限制开放CC BY-NC-SA浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Jingli]的文章
[Li, Shuling]的文章
[Wang, Lijuan]的文章
百度学术
百度学术中相似的文章
[Zhao, Jingli]的文章
[Li, Shuling]的文章
[Wang, Lijuan]的文章
必应学术
必应学术中相似的文章
[Zhao, Jingli]的文章
[Li, Shuling]的文章
[Wang, Lijuan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。