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Optimizing production of asperolide A, a potential anti-tumor tetranorditerpenoid originally produced by the algal-derived endophytic fungus Aspergillus wentii EN-48
Xu Rui1,2; Li Xiaoming1; Xu Gangming1; Wang Bingui1
2017-05-01
发表期刊CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
卷号35期号:3页码:658-663
文章类型Article
摘要The marine algal-derived endophytic fungus Aspergillus wentii EN-48 produces the potential anti-tumor agent asperolide A, a tetranorlabdane diterpenoid active against lung cancer. However, the fermentation yield of asperolide A was very low and only produced in static cultures. Static fermentation conditions of A. wentii EN-48 were optimized employing response surface methodology to enhance the production of asperolide A. The optimized conditions resulted in a 13.9-fold yield enhancement, which matched the predicted value, and the optimized conditions were successfully used in scale-up fermentation for the production of asperolide A. Exogenous addition of plant hormones (especially 10 mu mol/L methyl jasmonate) stimulated asperolide A production. To our knowledge, this is first optimized production of an asperolide by a marine-derived fungus. The optimization is Effective and valuable to supply material for further anti-tumor mechanism studies and preclinical evaluation of asperolide A and other norditerpenoids.
关键词Aspergillus Wentii Asperolide a Anti-tumor Agent Fermentation Optimization
DOI10.1007/s00343-017-6028-2
收录类别SCI
语种英语
WOS记录号WOS:000399168400020
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文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/136720
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol,Lab Marine Biol & Biotec, Qingdao Natl Lab Marine Sci & Technol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Xu Rui,Li Xiaoming,Xu Gangming,et al. Optimizing production of asperolide A, a potential anti-tumor tetranorditerpenoid originally produced by the algal-derived endophytic fungus Aspergillus wentii EN-48[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2017,35(3):658-663.
APA Xu Rui,Li Xiaoming,Xu Gangming,&Wang Bingui.(2017).Optimizing production of asperolide A, a potential anti-tumor tetranorditerpenoid originally produced by the algal-derived endophytic fungus Aspergillus wentii EN-48.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,35(3),658-663.
MLA Xu Rui,et al."Optimizing production of asperolide A, a potential anti-tumor tetranorditerpenoid originally produced by the algal-derived endophytic fungus Aspergillus wentii EN-48".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 35.3(2017):658-663.
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