Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas | |
Liu, Zhaoqun1,3 ; Zhou, Zhi1; Jiang, Qiufen1; Wang, Lingling2; Yi, Qilin2; Qiu, Limei1; Song, Linsheng2
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| 2017 | |
| 发表期刊 | OPEN BIOLOGY
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| 卷号 | 7期号:1 |
| 文章类型 | Article |
| 摘要 | The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocyteswas characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. |
| 关键词 | Crassostrea Gigas Neuroendocrine Immunomodulatory Axis Circulating Haemocyte Membrane Receptor Immune Regulation |
| DOI | 10.1098/rsob.160289 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000393382200012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/136335 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Dalian Ocean Univ, Minist Agr, Key Lab Mariculture & Stock Enhancement North Chi, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Zhaoqun,Zhou, Zhi,Jiang, Qiufen,et al. The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas[J]. OPEN BIOLOGY,2017,7(1). |
| APA | Liu, Zhaoqun.,Zhou, Zhi.,Jiang, Qiufen.,Wang, Lingling.,Yi, Qilin.,...&Song, Linsheng.(2017).The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas.OPEN BIOLOGY,7(1). |
| MLA | Liu, Zhaoqun,et al."The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas".OPEN BIOLOGY 7.1(2017). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| The neuroendocrine i（937KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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