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The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas
Liu, Zhaoqun1,3; Zhou, Zhi1; Jiang, Qiufen1; Wang, Lingling2; Yi, Qilin2; Qiu, Limei1; Song, Linsheng2
2017
Source PublicationOPEN BIOLOGY
Volume7Issue:1
SubtypeArticle
AbstractThe neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocyteswas characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network.
KeywordCrassostrea Gigas Neuroendocrine Immunomodulatory Axis Circulating Haemocyte Membrane Receptor Immune Regulation
DOI10.1098/rsob.160289
Indexed BySCI
Language英语
WOS IDWOS:000393382200012
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/136335
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Dalian Ocean Univ, Minist Agr, Key Lab Mariculture & Stock Enhancement North Chi, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhaoqun,Zhou, Zhi,Jiang, Qiufen,et al. The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas[J]. OPEN BIOLOGY,2017,7(1).
APA Liu, Zhaoqun.,Zhou, Zhi.,Jiang, Qiufen.,Wang, Lingling.,Yi, Qilin.,...&Song, Linsheng.(2017).The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas.OPEN BIOLOGY,7(1).
MLA Liu, Zhaoqun,et al."The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas".OPEN BIOLOGY 7.1(2017).
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